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Completed

NCT Number: NCT02496936

Acute Effects of Fats on Satiety and Energy Needs

The purpose of this study is to assess the acute effect of dietary fat on satiety and energy metabolism.

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Key information

Age range

18 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

USDA Grand Forks Human Nutrition Research Center

Grand Forks, North Dakota, 58203, United States

About this study

The influences of specific dietary fat sources on satiety, appetite and energy utilization remains unclear; evidence is lacking on whether responses vary according to acute intake. The researchers will use a controlled setting to determine whether the source of dietary fat is related to perceived satiety, satiety hormone responses, and energy expenditure by conducting experiments to evaluate short term (acute) effects.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • body mass index between 18.0-34.9 kg/m2
  • free of major diagnosed, untreated medical conditions
  • controlled hypertension
  • non-smoking or use of other tobacco products, including e-cigarettes
  • not taking steroid-based medications
  • not planning to or currently attempting to gain or lose weight
  • willing to comply with study demands
  • use of oral contraceptives
  • low intake of long chain omega 3 fatty acids

Exclusion criteria

  • diagnosed eating disorders
  • diabetes (blood sugar ≥ 126 mg/dl)
  • hypertension (systolic ≥ 160 mmHg or diastolic > 100 mmHg)
  • diagnosed cardiovascular, pulmonary, skeletal and metabolic disease
  • currently pregnant or planning to become pregnant, or lactating
  • taking medications known to affect appetite, blood lipids, body composition, body weight, or food intake (appetite control drugs, steroids, antidepressants)

Treatment and study plan

SFA

Other

High saturated fatty acid/SFA oil source

MUFA

Other

High monounsaturated fatty acid/MUFA oil source

PUFA-LA

Other

High polyunsaturated fatty acid (linoleic)/PUFA-LA oil source

ALA

Other

High polyunsaturated fatty acid (alpha-linolenic)/ALA oil source

LCn3

Other

High polyunsaturated fatty acid (omega-3)/LCn3 oil source

Primary outcomes

  1. Acute effect of fat intake on energy expenditure as determined by metabolic rate

    Time frame: Incremental Area Under the Curve (iAUC) of metabolic rate from 0 to 4 hours

Sponsors and collaborators

Lead sponsor

USDA Grand Forks Human Nutrition Research Center

Fed

Registry information

Important dates

Study start
2015
Primary completion
2019
Study completion
2019
First posted
Jul 14, 2015
Registry last updated
Aug 4, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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