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OpenTrials
Completed

NCT Number: NCT06017154

Acute Effect of Motor-Cognitive Training

Participants will complete a functional MRI to evaluate brain activation, functional connectivity, and behavioral performance immediately before and after a training program (approximately 30 minutes). The training program will comprise of integrate neuromuscular (agility, dynamic postural stability, shuffling, rapid acceleration/deceleration, plyometrics, lateral shuffle, and core stability) and cognitive (reaction time, processing speed, task switching, decision-making, and working memory) challenges.

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Key information

Age range

18 year–25 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

University of Kentucky

Lexington, Kentucky, 40506, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Physically active

Exclusion criteria

  • Injury to the muscle or bone (upper extremity, lower extremity, or back) within the past 3 months
  • Had musculoskeletal surgery or fracture (required open reduction internal fixation or within the last 12 months)
  • Had a concussion or mild head injury within the last year
  • Have been diagnosed with any kind of neurological, vestibular, or visual disturbance that impairs mobility
  • Currently taking medications that affect the central nervous system
  • Pregnant or suspicions of being pregnant
  • Have metal fragments, pins, plates, or clips, shrapnel, body piercings that cannot be removed, have surgical implants or orthodontics that cannot be removed
  • Have claustrophobia
  • Have a history of cognitive impairment

Treatment and study plan

Motor-Cognitive Training Program

Other

The training will incorporate cognitive tasks which focus on reaction time, processing speed, working memory, cognitive flexibility, and inhibitory control using visual stimuli on a screen or through sensors which illuminate using LED lights. These cognitive tasks will be performed while also executing physical performance tasks that challenge static and dynamic postural stability, lateral movement, agility, and other movement patterns. The training session will last approximately 30 minutes and participants will complete up to 5 exercises

Primary outcomes

  1. Change in brain activation

    Time frame: 2 hours, pre-training session and immediately post-training session

    During the task-based functional MRI scan the participant will complete a task-switching cognitive task, where participants have to identify two possible shapes (circle or square), in one of two possible colors (red or blue). They will respond using a trigger under their left and right foot. The level of brain activation during the task will be captured and reported.

  2. Change in functional connectivity

    Time frame: 2 hours, pre-training session and immediately post-training session

    The participant will complete a resting-state functional MRI scan in which they will lay still in the scanner. No task is performed during this scan. Functional connectivity (functionally related regions of the brain that are co-activated) during the scan will be captured and reported.

  3. Change in reaction time

    Time frame: 2 hours, pre-training session and immediately post-training session

    During the task-based functional MRI scan the participant will complete a task-switching cognitive task, where participants have to identify two possible shapes (circle or square), in one of two possible colors (red or blue). They will respond using a trigger under their left and right foot. The reaction time in milliseconds will be captured. The change in reaction time from pre to post training session will be reported.

  4. Change in accuracy

    Time frame: 2 hours, pre-training session and immediately post-training session

    During the task-based functional MRI scan the participant will complete a task-switching cognitive task, where participants have to identify two possible shapes (circle or square), in one of two possible colors (red or blue). They will respond using a trigger under their left and right foot. The percent of correct responses (accuracy) will be captured. The change in accuracy from pre to post training session will be reported.

Secondary outcomes

  1. Demographic/Injury History Form

    Time frame: Once, pre-training

    The demographic and injury history form is designed to capture: 1) information about the participant including age, height, weight, race, ethnicity, 2) information related to sports participation, and 3) information related to past injuries or medical conditions which are relevant to the study.

  2. Defense Veterans Pain Rating Scale

    Time frame: Once, pre-training

    The Defense Veterans Pain Rating Scale is a valid 5-item scale to assess pain magnitude and pain interference. This scale ranges from 0 to 10, 0 indicating no pain/interference and 10 indicating as bas as it could be/complete interference.

  3. Modified Disablement In Physically Active Scale

    Time frame: Once, pre-training

    16-item patient-reported outcome instrument that assesses physical and psychosocial status.This scale ranges from 0 to 4, 0 indicating no problem and 4 indicating severe.

  4. NASA Physical Activity Survey

    Time frame: Once, pre-training

    This survey asks individuals to self-report their general physical activity over the past week. This survey ranges from 0 to 10, 0 indicating sedentary and 10 indicating high physical activity.

  5. Heart rate

    Time frame: 35 minutes, during the training session

    Heart rate will be monitored with a noninvasive heart rate monitor that will be worn by the participant around the chest at the level of the xiphoid process. Resting heart rate will be collected prior to the start intervention then monitored and recorded throughout the training session.

  6. Average reaction time during the intervention

    Time frame: 30 minutes, during the training session

    Average reaction time in milliseconds will be captured during the exercises via light sensors.

  7. Misses during the training session

    Time frame: 30 minutes, during the training session

    The number of misses will be captured during the exercises via light sensors. A miss is considered when they deactivate the wrong sensor or don't deactivate the sensor quickly enough.

  8. Hits during the training session

    Time frame: 30 minutes, during the training session

    The number of hits will be captured during the exercises via light sensors. A hit is considered when they deactivate the correct sensor.

  9. Number of errors during the training session

    Time frame: 30 minutes, during the training session

    The number of errors will be captured during the exercises by visual observation. An error occurs when they do not complete they exercise correctly.

  10. Rate of perceived exertion

    Time frame: 30 minutes, during the training session

    After each exercise the participant will be asked to rate their perceived exertion on a scale from 6 to 20, 6 indicating low perceived exertion and 20 indicating high perceived exertion

  11. Perceived cognitive difficulty

    Time frame: 30 minutes, during the training session

    After each exercise the participant will be asked to rate their perceived cognitive difficulty on a scale from 1 to 10, 1 indicating low cognitive challenge and 10 indicating high cognitive challenge

Sponsors and collaborators

Lead sponsor

Ke'La H Porter

Other

Registry information

Official study title

The Acute Effects of Brain Activation and Functional Connectivity Following Motor-cognitive Training Using Functional MRI

Important dates

Study start
2023
Primary completion
2024
Study completion
2024
First posted
Aug 30, 2023
Registry last updated
Apr 15, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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