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NCT Number: NCT05694273

Acute Cerebrovascular Events in Patients Undergoing Catheter Ablation

This study aims to evaluate the incidence, clinical characteristics, and short-term prognosis of acute cerebrovascular events occurring in-hospital in patients with arrhythmias following catheter ablation. The goal is to provide evidence supporting the improvement of patient quality of life and reduction of in-hospital acute cerebrovascular complications in patients with post-ablation arrhythmias. This will also contribute to the evidence-based clinical management of such patients.

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Key information

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

About this study

With the steady development of catheter ablation, it has gradually become the main treatment of various arrhythmias. Antithrombotic and anticoagulant therapy after catheter ablation determines the occurrence of perioperative bleeding and ischemic events. However, the incidence, characteristics and short-term prognosis of secondary acute cerebrovascular events in patients with arrhythmia after catheter ablation have not been studied. Methods: This study was intended to retrospectively collect and analyze the case data and auxiliary examination results of patients with arrhythmia who underwent catheter ablation. To evaluate the incidence, clinical features and short-term prognosis of secondary acute ischemic and hemorrhagic cerebrovascular events in patients with arrhythmia after catheter ablation. In order to improve the quality of life of patients, reduce the secondary acute cerebrovascular complications in the hospital in patients with arrhythmia after catheter ablation, to provide evidence for promoting the clinical management of such patients, and to provide help for the maximum degree of prevention and control risk.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 1.Patients who undergo catheter ablation for arrhythmias.

Exclusion criteria

  • 1. Patients were diagnosed of acute cerebrovascular disease prior to radiofrequency catheter ablation;
  • 2. Patients < 18 years or > 80 years;
  • 3. Patients with uncomplete clinical data.

Treatment and study plan

Primary outcomes

  1. Incidence of MACCE

    Time frame: 3 months after enrollment

    Major adverse cardiovascular and cerebrovascular events, a composite of all-cause mortality, myocardial infarction and stroke. The data will be obtained at 3-month follow-up, according to medical records of all patients.

Secondary outcomes

  1. Incidence of all-cause mortality

    Time frame: 3 months after enrollment

    The data will be obtained at 3-month follow-up, according to medical records of all patients.

  2. Incidence of myocardial infarction

    Time frame: 3 months after enrollment

    The data will be obtained at 3-month follow-up, according to medical records of all patients.

  3. Incidence of stroke

    Time frame: 3 months after enrollment

    The data will be obtained at 3-month follow-up, according to medical records of all patients.

Study contacts

Contact information is provided by the study sponsor or research team.

Guoliang li

CONTACT

[email protected]

+8613759982523

Sponsors and collaborators

Lead sponsor

First Affiliated Hospital Xi'an Jiaotong University

Other

Collaborators

  • 521 Hospital of NORINCO Group
  • Ankang Central Hospital
  • Baoji Central Hospital
  • Chinese Academy of Medical Sciences, Fuwai Hospital
  • Fu Wai Hospital, Beijing, China
  • Fuwai Yunnan Cardiovascular Hospital
  • Luoyang Central Hospital
  • Shaanxi Provincial People's Hospital
  • Tianjin Medical University Second Hospital
  • Xiangyang Central Hospital

Registry information

Official study title

Acute Cerebrovascular Events in Patients Undergoing Catheter Ablation (CENTRAL): an Investigator-initiated, Multicenter Real-world Study

Acronym: CENTRAL

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Jan 23, 2023
Registry last updated
Apr 4, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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