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OpenTrials
Completed

NCT Number: NCT02153463

Activity in Tourette Syndrome

Tics are brief repetitive movements or vocalizations. Gilles de la Tourette's syndrome (TS) is a disorder characterized by recurrent motor and vocal tics. Tourette syndrome and tic disorders affect up to 8% of children. Peak severity of tic disorders occurs between the ages of 8 to 12 years, therefore during childhood and adolescence the most significant impacts are felt. The quality of life of young people with tics is lower than their peers' and tic severity predicts lower quality of life. Studies have also shown negative social perception toward children with tics.

Approximately 50% of patients with Tourette syndrome will have other diagnoses including attention deficit hyperactivity disorder (ADHD), obsessive compulsive disorder, anxiety and depression. Studies have shown improvements in ADHD with physical activity. ADHD and tic disorders are thought to involve the same areas of the brain; thus it is possible that tics might also improve with physical activity. However, no studies to date have examined this. The investigators predict that by implementing a motivational physical activity program, in conjunction with physical activity counseling, the investigators will be able to increase levels of physical activity in children with tics and Tourette syndrome, with a positive impact on tic severity.

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Key information

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Participants are between 8-16 years of age.
  • Participants are required to have a diagnosis of either Tourette Syndrome or Persistent (Chronic) Motor of Vocal Tic Disorder as per the DSM V.
  • Participants must be ambulatory.
  • Participants and parents must understand English or French.
  • Participants must be able and willing to complete the questionnaires.
  • Participants cannot have any changes to their medication for tics, or any other psychotropic medications for 4 weeks prior to and for the entire duration of the study

Exclusion criteria

  • Participants who cannot ambulate independently.
  • Participants who are not permitted to participate in physical education class at school.
  • Participants or families who are not willing to be randomly assigned to a study group.

Treatment and study plan

Physical activity counselling

Behavioral

Physical Activity Counselling weekly for 8 weeks

Primary outcomes

  1. Decrease in Yale Global Tic Severity Scale.

    Time frame: 8 weeks

Secondary outcomes

  1. Change in The Gilles de la Tourette Syndrome Quality of Life Scale for children and adolescents

    Time frame: 8 weeks

Other outcomes

  1. Change in PedsQL 4.0 measure

    Time frame: 8 weeks

  2. Change in KidScreen-27

    Time frame: 8 weeks

  3. Chang in The Children's Self-perceived Adequacy and Predilection for Physical Activity Questionnaire

    Time frame: 8 Weeks

  4. Change in step count via pedometer

    Time frame: 8 weeks

Sponsors and collaborators

Lead sponsor

Children's Hospital of Eastern Ontario

Other

Registry information

Official study title

Enhancing Physical Activity in Children With Tics and Tourette Syndrome: Impact on Tic Severity and Quality of Life

Important dates

Study start
2014
Primary completion
2014
Study completion
2014
First posted
Jun 3, 2014
Registry last updated
Aug 6, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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