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Completed

NCT Number: NCT03527901

Active Matrix Metalloproteinase-8 (aMMP-8) Chair-side Test in Different Periodontal Disease

The aim of this study to evaluate the diagnostic accuracy of a new qualitative aMMP-8 POC test in different periodontal health and disease and as compared to the established quantitative laboratory method (ELISA)

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Key information

Conditions

Periodontal Diseases Aggressive Periodontitis Chronic Disease Chronic Periodontitis Disease Attributes Mouth Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Periodontitis Stomatognathic Diseases

Age range

20 year–60 year

Sex eligibility

All sexes

Study type

Observational

About this study

MMP-8 has been reported to reflect the inflammatory status in periodontal tissues and, therefore represent as potential biomarkers of periodontitis. A positive aMMP-8 test could be an early indicator of these excessive and undesired tissue reactions.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Systemically healthy
  • Nonsmokers

Exclusion criteria

  • Participants were not included if they had systemic disease such as diabetes, cardiovascular.
  • Participants who took regular medications that could affect of periodontal tissue
  • Participants who received antibiotics less than 10 weeks before the study

Treatment and study plan

GCF collection with aMMP-8 chair side test

Diagnostic Test

Saliva Collection

Other

Primary outcomes

  1. aMMP-8 levels of GCF

    Time frame: 2 hours

    GCF levels measured by IFMA

Secondary outcomes

  1. Salivary MMP-8 levels

    Time frame: 2 hours

    Saliva levels measured by IFMA

Sponsors and collaborators

Lead sponsor

Aydin Adnan Menderes University

Other

Registry information

Official study title

Evaluation of Active Matrix Metalloproteinase-8 (aMMP-8) Chair-side Test in Different Periodontal Disease and Healthy Implants

Important dates

Study start
2015
Primary completion
2016
Study completion
2016
First posted
May 17, 2018
Registry last updated
May 17, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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