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OpenTrials
Completed

NCT Number: NCT02166580

Accuracy of CNAP PPV Under General Anaesthesia

Noninvasive pulse pressure variation for the guidance of perioperative fluid therapy is compared with the gold standard of invasive measurements. Cardiac output is derived by the PICCO monitor.

Hypothesis: Noninvasive CNAP PPV predicts fluid responsiveness. A grey zone for the prediction of fluid responsiveness will be defined.

Completed

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Key information

Conditions

General Anaesthesia

Age range

18 year–99 year

Sex eligibility

All sexes

Study type

Observational

Primary location

University Hospital, Schleswig-Holstein. Departement of Anaesthesiology and Intensive Care Medicine

Kiel, 24106, Germany

About this study

Accuracy of PPV measured by two devices,PICCO and CNAP, is compared with the manually calculated PPV from the arterial line waveform. Established tests like passive leg raising and end-expiratory occlusion are used for prediction of fluid responsiveness. Intraoperative events like volume challenge are monitored.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • major surgery
  • need for invasive arterial measurements

Exclusion criteria

  • age under 18
  • cardiac dysrhythmia
  • vascular pathology at punction site

Treatment and study plan

Primary outcomes

  1. Cardiac output

    Time frame: 1, 2, 5, 10, 15 and 20 minutes after volume challange and

    Improvement of cardiac output dependent on PPV before volume challenge

Sponsors and collaborators

Lead sponsor

University Hospital Schleswig-Holstein

Other

Registry information

Official study title

Comparison of the Non-invasive CNAP Pulse Pressure Variation With the Invasive Gold Standard

Important dates

Study start
2014
Primary completion
2015
Study completion
2015
First posted
Jun 18, 2014
Registry last updated
Jun 6, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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