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NCT Number: NCT07255950

Accuracy Between Transthoracal Needle Aspiration (TTNA) Techniques in Suspected Lung Cancer Patients

* The objective of this research is to determine the accuracy of different types of lung transthoracal needle aspiration (TTNA) i.e. jabbing-then-suction, suction-with-jabbing, and suction-only TTNA in patients with suspected lung cancer. * Researchers will compare these techniques to determine whether there are any quality differences in the obtained tumor samples

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Key information

Conditions

Lung Cancer (Diagnosis) Biopsy, Fine-Needle/Methods Bronchial Neoplasms Carcinoma, Bronchogenic Carcinoma, Non-Small-Cell Lung Disease Lung Diseases Lung Neoplasms Neoplasms Neoplasms by Site Pathologic Processes Pathological Conditions, Signs and Symptoms Respiratory Tract Diseases Respiratory Tract Neoplasms Thoracic Neoplasms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Universitas Gadjah Mada Academic Hospital (RSA UGM)

Yogyakarta, Special Region of Yogyakarta, 55291, Indonesia

Location status: Recruiting

Location contact

dr. Roihan Mohamad Iqbal

CONTACT

[email protected]

+6285933626780

dr. Siswanto, Sp.P(K)Onk

PRINCIPAL_INVESTIGATOR

About this study

During hospitalization for diagnostic testing, suspected lung cancer patients will undergo a transthoracic biopsy using three TTNA techniques, and core needle biopsy as the gold standard. The biopsy is performed in the operating room under local anesthesia and under the supervision of an anesthesiologist. The biopsy techniques used are routine procedures and therefore not as a new method. After the biopsy is completed, the patient is observed for at least 24 hours to observe potential complications.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with suspected lung cancer who will undergo diagnostic testing using ultrasound-guided TTNA of the lung with cell block and core biopsy.
  • Patients aged 18-75 years.
  • The tumor is located peripherally, attached to the chest wall.

Exclusion criteria

  • Patient refuses lung biopsy
  • Non-cooperative patient
  • Patient with respiratory failure, on positive pressure ventilation
  • Severe pulmonary emphysema
  • Contralateral pneumonectomy
  • Advanced pulmonary fibrosis
  • Platelet count <100,000/mm3 and international normalized ratio (INR) >1.4

Treatment and study plan

Jabbing-then-Suction, Suction-with-Jabbing, and Suction-only Transthoracal Needle Aspiration (TTNA) Techniques

Diagnostic Test

Each of patient will undergo three types of different transthoracal needle aspiration (TTNA)

Primary outcomes

  1. Quality of samples from different types of transthoracal needle aspiration (TTNA) technique

    Time frame: Immediate after biopsy procedure

    To determine the quality of samples between the jabbing-then-suction technique, the suction-with-jabbing technique, and the suction-only technique of transthoracic needle aspiration procedures in patients with unsuspected lung cancer. The sample quality assessed includes the adequacy of the number of tumor cells for molecular examination and the concordance between cytology sample of each type of TTNA technique.

Study contacts

Contact information is provided by the study sponsor or research team.

dr. Roihan Mohamad Iqbal

CONTACT

[email protected]

+6285933626780

Sponsors and collaborators

Lead sponsor

Gadjah Mada University

Other

Registry information

Official study title

Accuracy Between Jabbing-then-suction, Suction-with-jabbing, and Suction-only Transthoracal Needle Aspiration (TTNA) Techniques in Suspected Lung Cancer Patients

Important dates

Study start
2025
Primary completion
2025
Study completion
2026
First posted
Dec 1, 2025
Registry last updated
Dec 1, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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