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Completed

NCT Number: NCT06947564

AccuIMR Predicts Microvascular Obstruction and Infarct Size in STEMI Patients

In this study, we aimed to investigate the clinical significance of the angiography-based IMR calculation method (AccuIMR) and its prognostic assessment capability by evaluating the concordance or discordance between AccuIMR values and cardiac magnetic resonance (CMR) results.

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Key information

Conditions

Coronary Artery Disease Arterial Occlusive Diseases Arteriosclerosis Cardiovascular Diseases Coronary Disease Heart Diseases Infarction Ischemia Microvascular Coronary Artery Disease Myocardial Infarction Myocardial Ischemia Necrosis Pathologic Processes Pathological Conditions, Signs and Symptoms ST Elevation Myocardial Infarction STEMI - ST Elevation Myocardial Infarction Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Renji Hospital

Shanghai, Shanghai Municipality, 200127, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • (1) STEMI patients who underwent PCI within 12 hours of symptom onset.
  • (2) coronary microvascular function was assessed using contrast-enhanced CMR after PCI.

Exclusion criteria

  • (1) Suboptimal coronary angiographic images, including inadequate contrast opacification, unsatisfactory projection view, and severe overlap or distortion of the target vessel.
  • (2) Lacking two angiographic projections separated by at least 25° apart post-PCI.
  • (3) Inadequate CMR image quality

Treatment and study plan

cMR

Diagnostic Test

Coronary microvascular function was assessed using contrast-enhanced CMR after PCI.

Primary outcomes

  1. CMR

    Time frame: CMR was performed at a median of 5 days post-reperfusion.

    Contrast-enhanced CMR was performed on a 3.0-T scanner (Achieva TX, Philips Healthcare, Best, The Netherlands) . All sequences were acquired during breath-hold with a field of view at 350 × 350 mm2. Two experienced readers, blinded to clinical data, evaluated the CMR results using validated software (QMass MR 7.5, Medis, Leiden, The Netherlands). The acquired images were utilized to assess ventricular parameters and calculate the left ventricular ejection fraction (LVEF).

Secondary outcomes

  1. LDL-C, mmol/L

    Time frame: Blood samples were collected after a 12-hour fast in the second day post-PCI.

    Low-density cholesterol (LDL-C) is the cholesterol in low-density lipoprotein (LDL), which reflects how much LDL is present.

  2. HbA1c, %

    Time frame: Blood samples were collected after a 12-hour fast in the second day post-PCI.

    Hemoglobin a1c (HbA1c) is the combination of hemoglobin and blood sugar. Its concentration in the blood is stable and is not affected by short-term blood sugar concentrations. Hemoglobin A1C has obvious clinical value in the diagnosis of diabetes.

Sponsors and collaborators

Lead sponsor

RenJi Hospital

Other

Registry information

Official study title

Angiography-derived Index of Microcirculatory Resistance Predicts Microvascular Obstruction and Infarct Size in Patients With ST-segment-elevation Myocardial Infarction

Important dates

Study start
2012
Primary completion
2023
Study completion
2024
First posted
Apr 27, 2025
Registry last updated
Apr 27, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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