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Completed

NCT Number: NCT04163484

Contrast-associated Acute Kidney Injury in Patients With Different Types of Coronary Artery Disease

The goal of the study is to assess the prevalence of contrast-associated acute kidney injury in patients with stable coronary artery disease, ST-elevation myocardial infarction and unstable angina/NSTEMI, assess the risk factors of contrast-induced acute kidney injury development and the influence of contrast-induced kidney injury on 1-year prognosis.

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Key information

Conditions

Coronary Artery Disease Acute Kidney Injury Angina Pectoris Angina, Stable Angina, Unstable Arterial Occlusive Diseases Arteriosclerosis Cardiovascular Diseases Chest Pain Contrast-induced Nephropathy Coronary Disease Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Heart Diseases Infarction Ischemia Kidney Diseases Male Urogenital Diseases Myocardial Infarction Myocardial Ischemia NSTEMI - Non-ST Segment Elevation MI Necrosis Neurologic Manifestations Non-ST Elevated Myocardial Infarction Pain Pathologic Processes Pathological Conditions, Signs and Symptoms Renal Insufficiency ST Elevation Myocardial Infarction STEMI - ST Elevation Myocardial Infarction Signs and Symptoms Urogenital Diseases Urologic Diseases Vascular Diseases

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Sechenov University

Moscow, Russia

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Males and females aged 18-80
  • Stable CAD receiving optimal medical treatment requiring PCI or STEMI or NSTEMI
  • Intra-arterial injection of iodinated contrast media
  • Informed consent

Exclusion criteria

  • Age less than 18
  • Pregnancy, lactation
  • Refuse to sign the informed consent
  • Contraindications for PCI
  • Other conditions affecting prognosis (oncology, liver failure etc)
  • CKD stage 4-5
  • Patients receiving nephrotoxic drugs

Treatment and study plan

Iodinated contrast

Other

Intra-arterial injection of iodinated contrast media during percutaneous coronary intervention

Primary outcomes

  1. Contrast associated acute kidney injury

    Time frame: 48-72 hours

    Number of patients with contrast associated kidney injury after contrast exposure

Secondary outcomes

  1. Overall mortality

    Time frame: 1 year

  2. Cardiovascular mortality

    Time frame: 1 year

  3. Myocardial infarction

    Time frame: 1 year

    Number of patients with myocardial infarction

  4. Stroke

    Time frame: 1 year

  5. Repeat revascularization

    Time frame: 1 year

    PCI or CABG

  6. Repeat hospitalisation

    Time frame: 1 year

  7. Acute decompensation of heart failure

    Time frame: 1 year

    Number of patients with acute decompensation of heart failure

  8. Chronic kidney disease progression

    Time frame: 1 year

    Progression of chronic kidney disease in patients with decreased glomerular filtration rate on inclusion

  9. New-onset dialysis

    Time frame: 1 year

    Number of patients with new-onset dialysis

Sponsors and collaborators

Lead sponsor

I.M. Sechenov First Moscow State Medical University

Other

Registry information

Important dates

Study start
2019
Primary completion
2022
Study completion
2024
First posted
Nov 14, 2019
Registry last updated
Oct 8, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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