Abuse Potential of Single Doses of Lorcaserin in Healthy Recreational Polydrug Users

Inclusion criteria

• Healthy male or female subjects 18 to 55 years of age, inclusive.
• Body mass index (BMI) within the range of 18 to 33 kg/m2, inclusive, and a minimum weight of at least 50 kg at Screening.
• Free from any clinically significant medical or psychiatric abnormality
• Recreational polydrug user with a history of psychedelic and depressant drug use,and at least one occasion of use in the past 3 months.
• Female subjects must have a negative serum pregnancy test at Screening and urine pregnancy test at each admission.
• Female subjects of childbearing potential must be practising abstinence or using and willing to continue using a medically acceptable form of birth control for at least 1 month after the last study drug administration. Male subjects who have female partners of childbearing potential must ensure that their partner use an acceptable method of contraception.
• Willingness to take a drug that might alter perception in a controlled setting.

Exclusion criteria

A subject will not be considered eligible to participate in this study, if any one of the following exclusion criteria is satisfied:

• A history or presence of drug or alcohol dependence (excluding nicotine and caffeine).
• Use of non-prescription, prescription medication or natural health products (except acetaminophen, vitamin or mineral supplements, acceptable forms of birth control, and hormone replacement) within 7 days prior to first drug administration in the qualification phase and throughout the study.
• Use of SSRIs (e.g. fluoxetine, paroxetine, citalopram) within 14 days prior to first drug administration in the qualification phase and throughout the study.
• History of allergy or hypersensitivity to the study drugs
• Female subjects who are currently pregnant or lactating or who are planning to become pregnant within 30 days of last study drug administration
• Treatment with any investigational drug within 30 days prior to first drug administration during the qualification phase.