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NCT Number: NCT07274150

Abdominal Aortic Junction Tourniquet (AAJT-S) for Non-compressible Torso Haemorrhage in the Prehospital and Emergency Room Setting

This study seeks to evaluate the feasibility of a Abdominal Aortic Balloon Occlusion of the Aorta (AAJT-S) in exanguinating trauma patients with non-compressible truncal haemorrhage in the emergency room and the pre-hospital setting.

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Key information

Conditions

Exanguination Multiple Trauma NCTH Polytrauma Wounds and Injuries

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Medical University of Graz

Graz, Styria, 8010, Austria

Location contact

Gabriel Honnef, MD, PhD

CONTACT

[email protected]

06509160890

Gabriel Honnef, MD, PhD

PRINCIPAL_INVESTIGATOR

Paul Puchwein, MD, PhD

SUB_INVESTIGATOR

Philipp Zoidl, MD

SUB_INVESTIGATOR

CONTACT

[email protected]

About this study

Much like REBOA, AAJT-S can potentially stop blood flow distal to the device and therefore improve proximal aortic perfusion, minimize haemorrhage and stabilize patients until definite surgical repair/bleeding control is feasible. In contrast to REBOA, there is no need of femoral access and therefore, appropriate training is easily achieved.

This study seeks to gather further information on the benefits and potential harms of this intervention on a multicentre level.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Written consent of the participant after being informed
  • Aged, or believed to be aged, 18 years or above
  • Confirmed or suspected life-threatening lower body trauma (i.e. signs of inadequate perfusion of tissues, tachycardia, hypotension, suspected blood loss)
  • Thought to benefit from trauma resuscitation with AAJT-S or REBOA zone III
  • Traumatic cardiac arrest

Exclusion criteria

-

Treatment and study plan

Primary outcomes

  1. effective placement of the device

    Time frame: 1 hour

    cessation of bloodflow distal to the device

Secondary outcomes

  1. Outcome Measure

    Time frame: 30 days

    30-day in hospital mortality

  2. Complications

    Time frame: 90 days

    Occurrence of complications of device application

  3. hemodynamic improvement after application

    Time frame: 1 hour

    lower hart rate / higher blood pressure (improvement in bpm/mmHg)

Study contacts

Contact information is provided by the study sponsor or research team.

Gabriel Honnef, MD, PhD

CONTACT

[email protected]

+436509160890

Sponsors and collaborators

Lead sponsor

Medical University of Graz

Other

Registry information

Official study title

Abdominal Aortic Junction Tourniquet (AAJT-S) for Non-compressible Torso Haemorrhage A Prospective Multicentre-study

Important dates

Study start
2026
Primary completion
2028
Study completion
2028
First posted
Dec 10, 2025
Registry last updated
Dec 10, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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