A Test to Predict the Hemolytic Potential of Drugs in G6PD Deficiency

This study will evaluate a new and safe testing method for identifying medicines that can cause problems in glucose-6-phosphate dehydrogenase (G6PD) deficient individuals. We are looking for volunteers with G6PD deficiency who would be willing to donate blood samples.

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Key information

Conditions

Glucosephosphate Dehydrogenase Deficiency Anemia Anemia, Hemolytic Anemia, Hemolytic, Congenital Carbohydrate Metabolism, Inborn Errors Chemically-Induced Disorders Congenital, Hereditary, and Neonatal Diseases and Abnormalities Drug-Related Side Effects and Adverse Reactions Favism Foodborne Diseases Genetic Diseases, Inborn Hematologic Diseases Hemic and Lymphatic Diseases Hemolysis Metabolic Diseases Metabolism, Inborn Errors Nutritional and Metabolic Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Plant Poisoning Poisoning

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Walter Reed Army Institute of Research

Silver Spring, Maryland, 20910, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion:

Normal clinical evaluation
Willing and able to make all scheduled visits

Exclusion:

pregnant or planning pregnancy
Have taken any anti-malarial medication in past month
Positive blood tests for HIV and specific types of hepatitis
Allergic to primaquine

Treatment and study plan

Primaquine

Drug

Primary outcomes

Difference in degree of hemolysis of G6PD(-) red blood cells in treated vs untreated matched samples.

Sponsors and collaborators

Lead sponsor

Walter Reed Army Institute of Research (WRAIR)

Fed

Registry information

Official study title

A New Test to Predict the Hemolytic Potential of Drugs in G6PD Deficiency

Important dates

Study start: 2003
Study completion: 2006
First posted: Jan 21, 2004
Registry last updated: Jul 27, 2010

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed