A Systematic Echography During Intubation Procedure to Predict Cardiovascular Collapse

In the operating room, most intubation procedures (IP) are scheduled and performed on hemodynamically stable patients. In the ICU, IP is frequently performed in emergent patients, because of unstable hemodynamics and/or acute respiratory failure, and complicated by a subsequent cardiovascular collapse. Transthoracic echocardiography (TTE) has become readily available in most ICUs for several years. Echocardiography enables to perform a noninvasive hemodynamic evaluation (cardiac function and volemia status).

We hypothesized that performing a TTE prior to IP may help to predict cardiovascular collapse and its components.

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Key information

Conditions

Intubation

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

CHRU de Brest, Brest, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patient requiring endotracheal intubation

Exclusion criteria

Age < 18 yrs
Pregnancy
Amputation of a lower limb
Passing leg raising contraindication: intracranial hypertension with invasive monitoring, fracture of the pelvis or limbs
Patients under administrative protective measures
Severe cardiovascular collapse before intubation
Severe cardiogenic pulmonary oedema

Treatment and study plan

Primary outcomes

Subsequent cardiovascular collapse related to intubation

Time frame: Within 15 minutes of intubation

Mean arterial pressure drop < 60 mmHg

Secondary outcomes

Ultrasound parameters to predict fluid responsiveness

Time frame: 30 minutes before intubation, less than 30 minutes after intubation, 1 minutes after lifting legs and 3 hours after intubation

Transthoracic echocardiography parameters to predict fluid responsiveness

Sponsors and collaborators

Lead sponsor

University Hospital, Brest

Other

Registry information

Official study title

A Systematic Ultrasound Assessment During Intubation Procedure to Predict Cardiovascular Collapse Related to Intubation in the Intensive Care Unit: a Prospective, Multiple-center Study

Acronym: EPIC

Important dates

Study start: 2017
Primary completion: 2017
Study completion: 2018
First posted: Jun 12, 2017
Registry last updated: Aug 13, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed