A Study to Investigate Weight Management With LY3549492 Compared With Placebo in Adult Participants With Obesity or Overweight

Inclusion criteria

W8M-MC-GN01:

• Assigned male at birth
• Assigned female at birth, who are of non-childbearing potential

W8M-MC-CWMM:

• Have a BMI of

• ≥ 30 kilograms per square meter (kg/m²) or
• ≥ 27 kg/m² and < 30 kg/m² with at least one weight-related comorbidity
• Have had a stable body weight for the 3 months prior to randomization (<5% body weight gain and/or loss)

Exclusion criteria

W8M-MC-GN01:

• Have Type 2 Diabetes Mellitus or Type 1 Diabetes Mellitus
• Have a history of acute or chronic pancreatitis
• Have renal impairment
• Individuals who are of childbearing potential

W8M-MC-CWMM:

• Have a prior or planned surgical treatment for obesity, except prior liposuction or abdominoplasty, if performed >1 year prior to screening.
• Have type 1 diabetes mellitus, latent autoimmune diabetes in adults, or history of ketoacidosis or hyperosmolar coma.
• Have poorly controlled hypertension.
• Have signs and symptoms of any liver disease other than nonalcoholic fatty liver disease.
• Have any of the following cardiovascular conditions within 3 months prior to screening:

• acute myocardial infarction
• cerebrovascular accident (stroke)
• unstable angina, or
• hospitalization due to congestive heart failure.
• Have a history of symptomatic gallbladder disease within the past 2 years
• Have a lifetime history of suicide attempts.