A Study to Evaluate the Effect of a Topical Retinol on Epigenetic Changes and Expression of Certain Genes in the Skin Using Non-invasive Measurements

This is a randomized study. Participants will be randomly assigned to either the intervention cell and receive a cleanser, a sunscreen serum, and a night cream or the control cell and receive a cleanser and a sunscreen serum to use at home for 10 weeks. Participants will be randomized and receive products at Visit 1 (Screening/Baseline) conducted at Day 0 and return to the clinical site at Day 28 for Visit 2, and at Day 71 for Visit 3.

Inclusion criteria

• Has clinically determined moderate photodamage (defined as a score of 4 - 6 on a 0- 9-point scale) on the face at Visit 1.
• Is able to read, write, speak, and understand English.
• Generally in good health.
• Intends to complete the study and is willing and able to follow all study instructions.

Exclusion criteria

• Has known allergies or negative reactions to common topical skincare products, adhesives, latex, or ingredients in the study products.
• Has clinically active bacterial, fungi, or viral skin infection or has frequent skin infections.
• Presents with a skin condition that may increase risk to the subject, influence study results, or interfere with study evaluations (e.g. acne, psoriasis, eczema, atopic dermatitis, cutaneous xerosis, erythema, active skin cancer, tattoos, scarring, scratches/broken skin, sunburn, excessive hair growth, or very uneven skin tone) as determined by the principal investigator (PI).
• Has self-perceived sensitive skin.
• Is a regular (occasional to daily) smoker of cigarettes or user of electronic cigarettes (vaping pens).
• Is a regular (occasional or frequent) user of tanning beds and/or self-tanning products.
• Has had a surgical or aesthetic procedure in the last 3 months that can affect facial wrinkles or facial pigmentation (e.g. botulinum toxin (Botox) injections, chemical peels, laser-based therapies to the face, or face lift surgery).
• Has self-reported Type 1 or Type 2 diabetes or is taking insulin or another anti- diabetic medication.
• Is taking a medication that could mask a negative reaction or influence study results, as determined by the PI.
• Is self-reported to be breastfeeding, pregnant or planning to become pregnant during the study.
• Has a history of or a current health/other condition/situation which may put the individual at significant risk, influence the study results, or interfere significantly with the individual's participation in the study.
• Is currently participating in any other clinical study or has participated in any product-use study within 30 days prior to the study visit.
• Is an employee/contractor or immediate family member of the PI, study site, or Sponsor.