A Study of the Relative Bioavailability of Single Dose RO4917838 and the Effect of Food in Healthy Volunteers

Inclusion criteria

• Healthy male and female volunteers, 18 to 65 years of age, inclusive
• Body mass index (BMI) 18 to 30 kg/m2 inclusive
• Healthy as determined by the Investigator on the basis of medical and surgical history and a complete physical examination
• Non-smoker or smoker of fewer than 10 cigarettes per day; subject must be able to refrain from smoking during the in-patient stays
• Females who are not postmenopausal or surgically sterile must agree to use two adequate methods of contraception as defined by protocol during the treatment period and for at least one month after the last dose of study drug

Exclusion criteria

• Any condition or disease detected during the medical interview/physical examination that would render the subject unsuitable for the study, place the subject at undue risk or interfere with the ability of the subject to complete the study in the opinion of the Investigator
• History of alcoholism, drug abuse and/or drug addiction within the last year prior to Period 1. Day -1 of the study
• History of any significant cardiovascular, hepatic, renal, respiratory, gastrointestinal, endocrine, immunologic, allergic, dermatologic, hematologic, neurologic, psychiatric disease, or cancer
• Any history of depressive episodes or treatment with antidepressants
• Any significant allergic reactions against any drug, or multiple allergies in the judgement of the Investigator
• Pregnant or lactating females
• Positive for hepatitis B, hepatitis C or HIV infection
• Participation in another investigational study of any type within 90 days of RO4917838 administration or within 6 times the elimination half-life of the tested drug, whichever is longer