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Completed

NCT Number: NCT01641055

A Study of the Effects of Fish Protein Intake on Glucose Regulation in Overweight and Obese Adults.

The purpose of this study is to compare the possible health benefits of intake of proteins from salmon, herring, cod and milk on glucose tolerance in overweight and obese adults. Overweight and obese subjects often have reduced glucose tolerance, and previous findings from a study on cod proteins suggested that glucose tolerance was improved.

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Key information

Conditions

Obesity Body Weight Nutrition Disorders Nutritional and Metabolic Diseases Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year–69 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Institute of Medicine, University of Bergen

Bergen, 5021, Norway

About this study

Participants receive 2.5g protein per day for 8 weeks as tablets.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • BMI above 27 kg/m2
  • healthy

Exclusion criteria

  • fasting blood glucose above 7 mM
  • medication that affects blood glucose, lipids and inflammatory status
  • pregnancy or breastfeeding
  • allergies to fish or milk
  • intentional weight loss and large fluctuation in body weight
  • a high consumption of fish
  • an extreme diet
  • use of fish oil, n-3 or multivitamin supplements

Treatment and study plan

Salmon Protein Hydrolysate

Dietary Supplement

2.5g salmon protein hydrolysate per day for 8wk.

Herring protein hydrolysate

Dietary Supplement

2.5g herring protein hydrolysate per day for 8wk.

Cod protein

Dietary Supplement

2.5g cod protein per day for 8wk.

Milk protein

Dietary Supplement

2.5g milk protein per day for 8wk.

Primary outcomes

  1. Glucose regulation

    Time frame: 8 weeks

    Glucose will be measured in fasting and postprandial samples

Secondary outcomes

  1. Changes in serum insulin, insulin C-peptide, non-esterified fatty acids, lipids, adiponectin, leptin and fatty acid composition

    Time frame: 8 weeks

  2. Changes in serum and urine concentrations of amino acids and their metabolites

    Time frame: 8 weeks

  3. Changes in serum concentrations of vitamins

    Time frame: 8 weeks

  4. Comparisons of metabolites and co-factors involved in one-carbon metabolism in serum and urine

    Time frame: 8 weeks

    Concentrations of relevant metabolites and co-factors were measured in serum and urine

Sponsors and collaborators

Lead sponsor

University of Bergen

Other

Collaborators

  • BlueProtein
  • NutriMar

Registry information

Official study title

A 8 wk Study to Compare the Effects of Proteins Various Fish Species (Salmon, Herring, Cod) and Milk on Glucose Regulation in Overweight and Obese Adults.

Acronym: FISK3

Important dates

Study start
2012
Primary completion
2012
Study completion
2012
First posted
Jul 16, 2012
Registry last updated
Apr 7, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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