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Completed

NCT Number: NCT07247357

A Study of LY4064809 in Healthy Adult Chinese Participants

The main purpose of this study is to measure how much LY4064809 gets into the bloodstream and how long it takes the body to eliminate it in healthy participants. It also looks at safety and tolerability in healthy participants. The study drug will be administered orally. The study will last approximately 21 days, excluding screening.

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Key information

Conditions

Age range

21 year–55 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1

Primary location

Lilly Centre for Clinical Pharmacology

Singapore, 138623

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Are native Chinese. To qualify as a native Chinese for the purpose of this study, all 4 of the participant's biological grandparents must be of exclusive Chinese descent and born in China
  • Are overtly healthy as determined by medical evaluation, including medical history, physical examination, vital signs, and electrocardiogram (ECG) at screening and admission
  • Have clinical laboratory test results within the normal range for the population or investigative site, or with abnormalities deemed not clinically significant by the investigator at screening
  • Have a body mass index within the range 18 to 32 kilogram per square meter (kg/m²)

Exclusion criteria

  • History or presence of any of the following conditions, deemed clinically significant by the investigator (or designee), which may significantly alter the absorption, metabolism, or elimination of drugs, constitute a risk when taking the study intervention, or interfere with the data interpretation:
  • metabolic disease, including congenital non-hemolytic hyperbilirubinemia, for example, Gilbert syndrome
  • bile duct disease, including removal of the gall bladder
  • digestive system disease
  • blood disease
  • disease of the nervous system
  • significant history of, or presence of, liver disease, including any abnormal liver function tests, as defined by aspartate aminotransferase, alanine transaminase, or transducin beta-like above the 1.5× upper limit of normal range per the laboratory's reference ranges at screening, or
  • clinically significant, active cardiovascular disease or history of heart attack within 6 months prior to the planned start of LY4064809
  • Have a 12-lead ECG abnormality at screening or admission
  • History of a major surgical procedure within 30 days prior to screening
  • Diagnosed or treated cancer within 5 years prior to screening
  • Have known allergies to LY4064809 or related compounds

Treatment and study plan

LY4064809

Drug

administered orally

Primary outcomes

  1. Pharmacokinetics (PK): Maximum Concentration (Cmax) of LY4064809

    Time frame: Predose on Day 1 Through Day 14

    PK: Cmax of LY4064809

  2. PK: Area Under the Concentration Versus Time Curve (AUC) of LY4064809

    Time frame: Predose on Day 1 Through Day 14

    PK: AUC of LY4064809

Sponsors and collaborators

Lead sponsor

Eli Lilly and Company

Industry

Collaborators

  • Scorpion Therapeutics, a wholly owned subsidiary of Eli Lilly and Company

Registry information

Official study title

A Phase 1, Open-Label Study of the Pharmacokinetics of LY4064809 in Healthy Adult Chinese Participants

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Nov 25, 2025
Registry last updated
Jan 16, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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