Recruiting

NCT Number: NCT04012658

A Registered Cohort Study on Wilson's Disease

The aim of this study is to determine the clinical spectrum and natural progression of Wilson's Disease in a prospective multicenter natural history study, to assess the clinical, genetic, epigenetic features and biomarkers of patients with Wilson's Disease to optimize clinical management.

Recruiting

Interested in participating?

Request Info

Key information

Conditions

Wilson's Disease Basal Ganglia Diseases Brain Diseases Brain Diseases, Metabolic Brain Diseases, Metabolic, Inborn Central Nervous System Diseases Congenital, Hereditary, and Neonatal Diseases and Abnormalities Digestive System Diseases Genetic Diseases, Inborn Hepatolenticular Degeneration Heredodegenerative Disorders, Nervous System Liver Diseases Metabolic Diseases Metabolism, Inborn Errors Metal Metabolism, Inborn Errors Movement Disorders Nervous System Diseases Neurodegenerative Diseases Nutritional and Metabolic Diseases

Sex eligibility

All sexes

Study type

Observational

Primary location

First Affiliated Hospital of Fujian Medical University

Fuzhou, China

Location status: Recruiting

Location contact

Jin He, MD

CONTACT

Ning Wanf, MD,PhD

SUB_INVESTIGATOR

Wan-Jin Chen, MD, PhD

PRINCIPAL_INVESTIGATOR

CONTACT

[email protected]

86-0591-87982772

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients with the genetic diagnosis of Wilson's Disease
Asymptomatic Wilson's Disease carriers
Relatives of Wilson's Disease patients or carriers
Unrelated healthy controls
Participants or Parent(s)/legal guardian(s) willing and able to complete the informed consent process

Exclusion criteria

Participants are unable to comply with study procedures and visit schedule

Treatment and study plan

No intervention

Other

No intervention

Primary outcomes

The change of Unified Wilson's Disease Rating Scale (UWDRS)

Time frame: Up to 30years

Disease severity will be assessed by application of the Unified Wilson's Disease Rating Scale (UWDRS), a clinical rating scale consists of three subscales. Higher UWDRS total scores indicate more severe disease.

Study contacts

Contact information is provided by the study sponsor or research team.

Jin He, MD

CONTACT

[email protected]

86-0591-87982772

Yi Lin, MD.PhD

CONTACT

[email protected]

8613615039153

Sponsors and collaborators

Lead sponsor

Wan-Jin Chen

Other

Registry information

Important dates

Study start: 2019
Primary completion: 2039
Study completion: 2049
First posted: Jul 9, 2019
Registry last updated: Sep 23, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Recruiting