Recruiting

NCT Number: NCT04008329

A Registered Cohort Study on Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a kind of motor neuron degeneration disorder without effective therapy. This registered cohort study will provide further insights into the clinical course of ALS, and investigate disease-relative risk factors and the genetic background of Chinese ALS patients.

Recruiting

Interested in participating?

Request Info

Key information

Conditions

Amyotrophic Lateral Sclerosis Central Nervous System Diseases Metabolic Diseases Motor Neuron Disease Nervous System Diseases Neurodegenerative Diseases Neuromuscular Diseases Nutritional and Metabolic Diseases Proteostasis Deficiencies Spinal Cord Diseases TDP-43 Proteinopathies

Sex eligibility

All sexes

Study type

Observational

Primary location

Department of Neurology, First Affiliated Hospital of Fujian Medical University

Fuzhou, Fujian, 350005, China

Location status: Recruiting

Location contact

Ning Wang, MD,PhD

PRINCIPAL_INVESTIGATOR

Ning Wang, PhD

CONTACT

[email protected]

086-591-87982772

Qi-Jie Zhang, PhD

CONTACT

[email protected]

086-591-87982772

Wan-Jian Chen

SUB_INVESTIGATOR

About this study

Amyotrophic lateral sclerosis (ALS) is the most common form of motor neuron disease (MND), which is characterized with highly clinical heterogeneity and no effective treatment is available now. The purpose of this registered cohort is to observe the natural history of ALS patients in China, and then identify some factors correlated with disease progression. Besides, ALS-related gene mutations will be screened and explore novel disease causing gene as well.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Amyotrophic Lateral Sclerosis patients fulfilling the El Escorial criteria (including definite, probable and possible)
Progressive muscular atrophy
Primary lateral sclerosis
Progressive bulbar palsy

Exclusion criteria

History of serious head trauma or neuropsychiatric disease
Decline to participate

Treatment and study plan

Primary outcomes

Age at death

Time frame: 10 years

the time when patient die
Age of endotracheal intubation or tracheotomy

Time frame: 10 years

the time for the patient accepted endotracheal intubation or tracheotomy

Study contacts

Contact information is provided by the study sponsor or research team.

Qi-Jie Zhang, PhD

CONTACT

[email protected]

086-591-87982772

Sponsors and collaborators

Lead sponsor

First Affiliated Hospital of Fujian Medical University

Other

Registry information

Important dates

Study start: 2019
Primary completion: 2029
Study completion: 2059
First posted: Jul 5, 2019
Registry last updated: Mar 22, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Recruiting