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Completed

NCT Number: NCT07439068

A-PRF and CGF in Palatal Donor Site Healing

The objective of this study was to compare and evaluate the effects of concentrated growth factor (CGF) and advanced platelet-rich fibrin (A-PRF) clot membranes on palatal epithelial wound healing and postoperative discomfort following free gingival graft (FGG) harvesting.

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Key information

Conditions

Free Gingival Graft

Age range

18 year–55 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2

Primary location

Ordu University

Ordu, 52100, Turkey (Türkiye)

About this study

The objective of this study was to compare and evaluate the effects of concentrated growth factor (CGF) and advanced platelet-rich fibrin (A-PRF) clot membranes on palatal epithelial wound healing and postoperative discomfort following free gingival graft (FGG) harvesting.

Fourty-five patients who underwent FGG harvesting were randomly assigned to three groups: (1) control group (n=15), receiving only a sterile gelatin sponge; (2) A-PRF group (n=15), receiving A-PRF clot membranes; and (3) CGF group (n=15), receiving CGF clot membranes at the donor site. The epithelization rate, color match, and sensation scores of the palatal wound were assessed at 1, 2, 3, and 4 weeks postoperatively. Pain levels, analgesic consumption, and bleeding time were self-reported by patients for the first 7 days of healing.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • at least 18 years old,
  • without systemic or periodontal diseases,
  • without medical contraindications to periodontal surgery
  • with full-mouth plaque control scores ≤ 20%
  • Gingival index scores ≤ 1

Exclusion criteria

  • smoking habits,
  • diabetes mellitus,
  • pregnancy or lactation,
  • removable upper denture,
  • regular medication that could interpose the healing process, undergoing bisphosphonate therapy, history of radiation therapy of the jaws, and follow-up consults

Treatment and study plan

Advanced platelet-rich fibrin

Procedure

Advanced platelet-rich fibrin membranes and free gingival graft

Concentrated growth factor

Procedure

Concentrated growth factor membranes and free gingival graft

Sterile gelatin sponge

Procedure

Sterile gelatin sponge and free gingival graft

Primary outcomes

  1. Epithelialization

    Time frame: Baseline

    Rate of re-epithelialization with re-total, partial, or none by dropping hydrogen peroxide (3%) on the wound surface

  2. Epithelialization

    Time frame: 1 week post-surgery

    Rate of re-epithelialization with re-total, partial, or none by dropping hydrogen peroxide (3%) on the wound surface

  3. Epithelialization

    Time frame: 2 week post-surgery

    Rate of re-epithelialization with re-total, partial, or none by dropping hydrogen peroxide (3%) on the wound surface

  4. Epithelialization

    Time frame: 3 week post-surgery

    Rate of re-epithelialization with re-total, partial, or none by dropping hydrogen peroxide (3%) on the wound surface

  5. Epithelialization

    Time frame: 4 week post-surgery

    Rate of re-epithelialization with re-total, partial, or none by dropping hydrogen peroxide (3%) on the wound surface

  6. Pain perception

    Time frame: Baseline

    Presence of pain perception on the Visual Analog Scale (VAS) pain scores (0: no pain, 1: minimal pain, 10: severe pain)

  7. Pain perception

    Time frame: 1st day after surgery

    Presence of pain perception on the Visual Analog Scale (VAS) pain scores (0: no pain, 1: minimal pain, 10: severe pain)

  8. Pain perception

    Time frame: 2nd day after surgery

    Presence of pain perception on the Visual Analog Scale (VAS) pain scores (0: no pain, 1: minimal pain, 10: severe pain)

  9. Pain perception

    Time frame: 3th day after surgery

    Presence of pain perception on the Visual Analog Scale (VAS) pain scores (0: no pain, 1: minimal pain, 10: severe pain)

  10. Pain perception

    Time frame: 4th day after surgery

    Presence of pain perception on the Visual Analog Scale (VAS) pain scores (0: no pain, 1: minimal pain, 10: severe pain)

  11. Pain perception

    Time frame: 5th day after surgery

    Presence of pain perception on the Visual Analog Scale (VAS) pain scores (0: no pain, 1: minimal pain, 10: severe pain)

  12. Pain perception

    Time frame: 6th day after surgery

    Presence of pain perception on the Visual Analog Scale (VAS) pain scores (0: no pain, 1: minimal pain, 10: severe pain)

  13. Pain perception

    Time frame: 7th day after surgery

    Presence of pain perception on the Visual Analog Scale (VAS) pain scores (0: no pain, 1: minimal pain, 10: severe pain)

  14. Pain perception

    Time frame: 14th day after surgery

    Presence of pain perception on the Visual Analog Scale (VAS) pain scores (0: no pain, 1: minimal pain, 10: severe pain)

  15. Pain perception

    Time frame: 21st day after surgery

    Presence of pain perception on the Visual Analog Scale (VAS) pain scores (0: no pain, 1: minimal pain, 10: severe pain)

  16. Pain perception

    Time frame: 28th day after surgery

    Presence of pain perception on the Visual Analog Scale (VAS) pain scores (0: no pain, 1: minimal pain, 10: severe pain)

Sponsors and collaborators

Lead sponsor

Ordu University

Other

Registry information

Official study title

Effects on Patients' Postoperative Morbidity and Donor Site Wound Healing of A-PRF and CGF Application After Free Gingival Graft Harvesting: A Comparative Randomized Clinical Trial

Acronym: FGG

Important dates

Study start
2020
Primary completion
2022
Study completion
2022
First posted
Feb 27, 2026
Registry last updated
Feb 27, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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