A Predictive Model for Early Metastasis in Cervical Cancer Patients After Radiotherapy

This study aims to help to screen out appropriate cases for consolidation therapy and more intensive follow up.

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Trial opening soon.

Key information

Conditions

Cervical Cancer Distant Metastasis Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Genital Diseases Genital Diseases, Female Genital Neoplasms, Female Neoplasms Neoplasms by Site Prognostic Model Radiotherapy Risk Factor Urogenital Diseases Urogenital Neoplasms Uterine Cervical Diseases Uterine Cervical Neoplasms Uterine Diseases Uterine Neoplasms

Age range

20 year–85 year

Sex eligibility

Female

Study type

Observational

Primary location

Fujian Cancer Hospital

Fuzhou, Fujian, 350014, China

About this study

Some cervical cancer patients experienced distant metastasis quickly after receiving complete radiotherapy and have a worse prognosis. However, there were few studies focused on these patients and with early distant metastasis. It is significant to predictive and screen out cervial cancer patients with a high risk of early metastasis for more comprehensive treatments and follow-up plans

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

patients confirmed as cervical cancer by biopsies and treated with radiotherapy were initially enrolled

Exclusion criteria

(1) patients treated with surgery. (2) patient received incomplete treatment somewhere else. (3) patients with cancer history. (4) patients with pelvic surgery history. (5) patients without complete pre-treatment medical information. (6) patients with unfinished radical radiotherapy. (7) patients suffered from metastasis within 3 months after radiotherapy. (8) patients without complete 1-year follow-up materials

Treatment and study plan

external pelvic beam radiotherapy (EBRT) followed by individualized high-dose-rate intracavitary brachytherapy (HDR-ICBT)

Radiation

Radical RT consisted of external pelvic beam radiotherapy (EBRT) and individualized high-dose-rate intracavitary brachytherapy (HDR-ICBT).Cisplatin-based concurrent chemoradiotherapy (CCRT) was recommended for CC patients unless for economic status, age consideration and patients' desires.

Primary outcomes

Early distant metastases

Time frame: 3-12months

Early distant metastasis defines as metastasis occurrence between 3 -12 months after radiotherapy.

Study contacts

Contact information is provided by the study sponsor or research team.

Yang Sun, PhD

CONTACT

[email protected]

+8615959028989

Sponsors and collaborators

Lead sponsor

Fujian Cancer Hospital

Other Gov

Registry information

Official study title

A Novel Predictive Model and Risk Stratification for Early Metastasis in Cervical Cancer Patients After Radiotherapy

Important dates

Study start: 2023
Primary completion: 2027
Study completion: 2027
First posted: Oct 26, 2023
Registry last updated: Oct 26, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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