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NCT Number: NCT07341984

A Physiotherapy Intervention Study in Patients With Amyotrophic Lateral Sclerosis (ALS)

This study investigates whether an individualized physiotherapy program, tailored to each patient's specific motor deficits, can better support physical function compared with usual care physiotherapy in people with ALS.

The individualized program is guided by diagnostic assessments using a robotic leg press system, which helps identify strengths and weaknesses in muscle function and movement control.

Participants will receive either individualized physiotherapy or standard physiotherapy and will be followed for 12 months. The aim of the study is to improve physiotherapy strategies for people with ALS in a safe and patient-centered manner.

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Key information

Conditions

Amyotrophic Lateral Sclerosis Central Nervous System Diseases Metabolic Diseases Motor Neuron Disease Nervous System Diseases Neurodegenerative Diseases Neuromuscular Diseases Nutritional and Metabolic Diseases Proteostasis Deficiencies Spinal Cord Diseases TDP-43 Proteinopathies

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • diagnosis of clinically probable, probable laboratory-supported, or definite ALS (revised El Escorial criteria) or upper motor neuron only (OPM classification [onset, propagation, motoneuron involvement])
  • age ≥18 years; ability to understand study information and provide written informed consent
  • Willingness and ability to perform individualized exercise according to the study protocol (approximately three to five sessions of 30 minutes per week) for the duration of the intervention period
  • Individuals of all sexes and gender identities are eligible for inclusion

Exclusion criteria

  • pregnancy, tracheostomy, continuous assisted ventilation, or other significant non-ALS pulmonary disease
  • other neurodegenerative or neuromuscular conditions that may confound assessments
  • concomitant life-threatening disease or impairment interfering with functional assessment

Treatment and study plan

Individualized Physiotherapy

Other

see above

Primary outcomes

  1. Climbing stairs (ALSFRS-R [amyotrophic lateral sclerosis functional rating scale - revised] - item 9: score range 0 to 4 with 4 indicating normal function)

    Time frame: 6 months

    funcitonal

Study contacts

Contact information is provided by the study sponsor or research team.

Charlotte Vogt

CONTACT

[email protected]

0041714943581

Oleksandra Hoptar

CONTACT

[email protected]

0041714943581

Sponsors and collaborators

Lead sponsor

Charlotte Vogt

Other

Registry information

Official study title

Individualized Physiotherapy Addressing Patient-Specific Deficits in Amyotrophic Lateral Sclerosis Compared to Usual Care Physiotherapy: A Prospective, Pseudorandomized, Controlled, Interventional Study

Acronym: Train ALS

Important dates

Study start
2025
Primary completion
2027
Study completion
2028
First posted
Jan 15, 2026
Registry last updated
Jan 15, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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