A Phase 1 Mass Balance Study of [¹⁴C]SSS17 in Healthy Chinese Males

Inclusion criteria

• Healthy adult male subjects aged 18-45 years .
• Body weight ≥50 kg .
• Normal findings on comprehensive health assessment.
• The subject demonstrates understanding of the trial's objectives, requirements, procedures, and potential adverse reactions; voluntarily participates; commits to complete all trial activities per protocol and comply with study regulations; with the informed consent process conducted in compliance with Good Clinical Practice ."

Exclusion criteria

• Subjects with abnormalities in the nervous system, respiratory system, cardiovascular system, digestive system, hematological and lymphatic systems, endocrine system, or musculoskeletal system that are deemed clinically significant by the investigator.
• History of organic heart disease
• History of hypersensitivity or allergy to active ingredients.
• Average daily smoking >5 cigarettes within 3 months prior to screening or inability to abstain during the trial.
• Average weekly alcohol intake >14 units within 3 months prior to screening or positive alcohol breath test.
• History of drug abuse or illicit drug use, or positive urine drug screen.
• Participation in any other investigational drug trial within 3 months prior to screening.
• Use of any prescription/non-prescription medication within 2 weeks prior to investigational product administration.
• History of needle/phobia or inability to tolerate venipuncture.
• Hemorrhoids/active perianal bleeding, chronic constipation/diarrhea or positive fecal occult blood test at screening.
• Occupational radiation exposure;
• Pregnancy plans during or within 1 year post-trial, or refusal to use strict contraception by subject/partner during and within 1 year post-trial.