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NCT Number: NCT07671638

Methodological Study of Exercise and Hypoxic Conditions in Healthy Subjects

The aim of this protocol is to assess physiological responses during various physical exercise protocols (whole-body exercise such as cycling or treadmill running, or localised exercise such as knee extension) and during inhalation of a gas mixtures with various oxygen contents (similar to exposure at high altitude).

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Key information

Conditions

Healthy Subjects (HS) Behavior Exercise Hypoxia Motor Activity Pathological Conditions, Signs and Symptoms Signs and Symptoms Signs and Symptoms, Respiratory

Age range

18 year–55 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy male or female volunteers
  • Aged 18-55
  • Body Mass Index <30 kg/m²
  • Participants covered by a social security scheme
  • Participants capable of signing an informed consent form
  • Negative pregnancy test and highly effective contraception for women of childbearing age

Exclusion criteria

  • Cardiorespiratory, metabolic and neurological disorders, or other conditions assessed during the inclusion consultation that may affect physiological responses to exercise or hypoxia
  • Pharmacological treatment taken during the study, other than oral or implantable contraceptive medication for female volunteers of childbearing age

Treatment and study plan

Exercise and hypoxia

Combination Product

Subjects will perform an exercise test while inhaling a hypoxic gas mixture

Primary outcomes

  1. Muscle oxygenation

    Time frame: During 5 minutes before starting the exercise test, continuously during the exercise test and during 10 minutes immediatly after the end of the exercise test

    Measured by NIRS in % saturation

Secondary outcomes

  1. Gas exchange

    Time frame: During 5 minutes before starting the exercise test, continuously during the exercise test and during 10 minutes immediatly after the end of the exercise test

    Oxygen consumption and cardon dioxide production measured at the mouth, measured in ml/min

  2. Heart rate

    Time frame: During 5 minutes before starting the exercise test, continuously during the exercise test and during 10 minutes immediatly after the end of the exercise test

    Measured by ECG in bpm

  3. Limb blood flow

    Time frame: During 5 minutes before starting the exercise test, continuously during the exercise test and during 10 minutes immediatly after the end of the exercise test

    Measured by Doppler ultrasound in ml/min

Study contacts

Contact information is provided by the study sponsor or research team.

Samuel Vergès

CONTACT

[email protected]

+33670395773

Sponsors and collaborators

Lead sponsor

University Hospital, Grenoble

Other

Collaborators

  • University Grenoble Alps

Registry information

Acronym: ExHyp

Important dates

Study start
2026
Primary completion
2031
Study completion
2032
First posted
Jun 26, 2026
Registry last updated
Jul 21, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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