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Completed

NCT Number: NCT06291090

A Multi-site Intervention to Expand Hospital Based OUD Treatment Provision

The investigators implemented a multi-site hospital-based opioid use disorder (OUD) treatment intervention across 12 hospitals in Colorado to address an OUD treatment gap among hospitalized adults with OUD.

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Key information

Conditions

Opioid Use Disorder Chemically-Induced Disorders Mental Disorders Narcotic-Related Disorders Opioid-Related Disorders Substance-Related Disorders

Age range

18 year–99 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Colorado Anschutz Medicl Campus

Aurora, Colorado, 80045, United States

About this study

The investigators implemented a multi-site hospital-based opioid use disorder (OUD) treatment intervention across 12 hospitals in Colorado to address an OUD treatment gap among hospitalized adults with OUD. The intervention included nurse driven universal screening for unhealthy substance use with a social work referral for a brief intervention when indicted, electronic health record-embedded protocols to assess for opioid withdrawal and to direct buprenorphine initiation, methadone orders for opioid withdrawal symptoms, and embedded links for post discharge addiction treatment referral. It also included clinician education and nursing education via video conference or in-person lectures. The intervention was supported by the health system Chief Medical Officer and involved subject matters expertise and representation from nursing leaders, social work leaders, and hospital medicine leaders. Outcomes assess include a pre/post implementation assessment of 1) change in buprenorphine prescribed in hospital and 2) discharge, 3) change in naloxone prescribed, 4) change in hospital based methadone prescribing, and 5) change in average clinical opioid withdrawal scale (COWS) score. investigators also assessed a pre/post survey of hospitalists physicians and advanced practice providers to assess their perception of hospital based OUD treatment provision.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Physicians, advanced practice providers, social workers, and nurses who work at any affiliated hospitals

Exclusion criteria

  • none

Treatment and study plan

OUD treatment intervention

Behavioral

Participants received education on the diagnosis and management of OUD, have access to protocols to walk them through assessment of OUD using Diagnostic and Statistical Manual, fifth Edition (DSM)-5, COWS score to calculate severity of opioid withdrawal, buprenorphine or methadone initiation with pre-populated orders, and clickable links for OUD treatment referral post discharge.

Primary outcomes

  1. Change in buprenorphine prescribing at hospital discharge

    Time frame: Calculate monthly prescribing rates over a three year time frame (including pre and post implementation) to assess for change

    Change in rate of buprenorphine prescribing at hospital discharge among patients with OUD before and after intervention implementation

Secondary outcomes

  1. Change in rates of methadone prescribing during hospitalization

    Time frame: Calculate monthly prescribing rates over a three year time frame (including pre and post implementation) to assess for change

    Change in rate of in hospital methadone prescribing among patients with OUD before and after intervention implementation

Other outcomes

  1. Change in average (mean) COWS score over time

    Time frame: Calculate mean monthly COWS scores over a three year time frame (including pre and post implementation) to assess for change

    Change in rate of in mean COWS score among patients with OUD before and after intervention implementation

  2. Change in naloxone prescribing at hospital discharge

    Time frame: Calculate monthly prescribing rates over a three year time frame (including pre and post implementation) to assess for change

    Change in rate of naloxone prescribing at hospital discharge among patients with OUD before and after intervention implementation

Sponsors and collaborators

Lead sponsor

University of Colorado, Denver

Other

Collaborators

  • National Institute on Drug Abuse (NIDA)

Registry information

Official study title

In Hospital Treatment of Opioid Use Disorder: Clinician Perspectives and Current Practices

Important dates

Study start
2023
Primary completion
2024
Study completion
2025
First posted
Mar 4, 2024
Registry last updated
May 1, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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