A Ketamine-assisted Group Therapy Intervention for Spanish-speaking Adults With Depression

Inclusion criteria

• Self-identifying Latinx, Spanish-speaking 2. Adults 18-64 years 3. Meet DSM-5 criteria for major depressive disorder as evaluated by study clinician 4. Montgomery-Asberg depression scale (MADRS) score of 20 or above at baseline 4. Participants must have an MGB psychiatrist and primary care provider.

Exclusion criteria

• History of primary psychotic disorder, by history
• History Bipolar I disorder, by history
• Unstable complex PTSD, as assessed by study clinician
• History of dissociative identity disorder
• History of neurocognitive disorder
• History of severe and/or recent substance use disorder, by history and as assessed by study clinician after clinical evaluation and interview
• Uncontrolled hypertension, tachycardia, or unstable cardiopulmonary disease, by history a. Blood pressure on initial screen must be <140/90 mmHg.
• History of aortic dissection
• History of myocardial infarction
• History of aneurysm
• History of hepatic impairment.
• History of epilepsy
• History of prior hypersensitivity to ketamine
• Body Mass Index greater than 35
• Body Mass Index less than 18.5
• Are pregnant, breastfeeding, or planning to become pregnant within 12 weeks of treatment completion
• Enrolled in other clinical trial for the treatment of depression or other behavioral health diagnosis
• Inability to provide consent.