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OpenTrials
Completed

NCT Number: NCT00868348

A Comparison of Naropin and Ketorolac for Postoperative Analgesia After Total Knee Arthroplasty

The purpose of this study is to determine wether ketorolac is effective in the treatment of postoperative pain after total knee arthroplasty

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Key information

Conditions

Postoperative Pain Neurologic Manifestations Pain Pain, Postoperative Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Aarhus University

Aarhus, 8000, Denmark

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Total knee arthroplasty
  • Age > 18
  • Tolerance for study drugs
  • Written informed consent

Exclusion criteria

-

Treatment and study plan

Ketorolac

Drug

30 mg (1 ml) infiltration combined with Intraarticular bolus injection of 120 mg (4 ml) ketorolac

Other names: Toradol

Saline

Drug

1 ml infiltration 4 ml intraarticular bolus injection of placebo

Primary outcomes

  1. Morphine Consumption

    Time frame: 48 hours after surgery

    Consumption of intravenous (i.v.) patient-controlled analgesia (PCA) morphine during the first forty-eight hours after surgery

Secondary outcomes

  1. Time to First i.v. Patient Controlled Analgesia (PCA) Morphine Request

    Time frame: within 48 hours after surgery

  2. Pain Intensity Scores During Walking

    Time frame: 6-24 hours postoperatively

    Pain intensity Visual Analogue Scale (VAS) (VAS; 0, no pain, and 100 mm, worst pain possible)

  3. Home Readiness

    Time frame: time to fulfilment of discharge criteria

    Ability to meet discharge criteria (home readiness)

  4. Length of Hospital Stay

    Time frame: From the day of surgery until discharge

  5. Pain Intensity During Daily Activity

    Time frame: 16 weeks after surgery

    Pain intensity Visual Analogue Scale (VAS) (VAS; 0, no pain, and 100 mm, worst pain possible)

Sponsors and collaborators

Lead sponsor

University of Aarhus

Other

Registry information

Official study title

Local Infiltration Analgesia for Total Knee Arthroplasty: Should Ketorolac be Added

Important dates

Study start
2009
Primary completion
2011
Study completion
2011
First posted
Mar 25, 2009
Registry last updated
Mar 10, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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