A Clinical Trial to Compare the Pharmacokinetics and Bioequivalence of "BR2008" With "BR2008-1" in Healthy Volunteers

<Inclusion Criteria>

• Healthy adults aged over 19 years at screening
• Those who have no congenital or chronic diseases and have no abnormal symptoms or findings based on medical examination results
• Determined to be eligible subjects as a result of clinical laboratory tests and electrocardiography performed according to this protocol at screening
• Those who have calculated body mass index(BMI) within the range of 18.0 to 30.0 kg/m2
• Those who do not have a history of the psychiatric diseases within the last 5 years before screening
• Those who do not have a history of gastrointestinal diseases (e.g., Crohn's disease, ulcer, acute or chronic pancreatitis, etc.) or gastrointestinal surgery (however, simple appendectomy or hernia repair are excluded) that may affect the absorption of drugs
• Voluntarily decide to participate in the study and provide written consent to follow the study directions after listening to and fully understanding the detailed explanation on this study

<Exclusion Criteria>

• Those who took drugs inducing and inhibiting drug-metabolizing enzymes, such as barbital, within 30 days prior to the first administration date, or took any drugs that may the clinical trial
• Those who continue to drink alcohol (Male: >5 units/week, Female: >2.5 units/week) within 1 month prior to the first administration date
• Those who continue to smoke (>10 cigarettes/day) or cannot stop smoking during hospitalization throughout the entire period from the date of 48 hours before the first administration of the investigational product to the last pharmacokinetic blood sampling
• Those who have been determined by the investigator to be ineligible to participate in the clinical trial
• Those who have participated in another clinical trial or bioequivalence test (the last day of administration of the investigational product or bioequivalence test drug) within 6 months prior to the first administration date
• Those who have donated whole blood within 2 months, or donated blood components (apheresis) within 2 weeks, or who have received a blood transfusion within 30 days prior to screening
• Those who do not agree to rule out the possibility of their and their spouses' or sexual partners' pregnancy using a medically acceptable methods of contraception throughout the entire period from the date of the first administration of the investigational product to 8 weeks after the last administration of the investigational product
• Those with severe hepatic impairment, or any of the following results in the screening tests

• Total bilirubin ≥ 1.5 x ULN
• AST(SGOT) or ALT(SGPT) ≥ 2 x ULN
• r-GTP ≥ 1.5 x ULN
• Those with severe renal impairment, or serum creatinine levels upper than 1.5 times of ULN
• Those with a predisposition to bleeding, or taking anticoagulants(Warfarin, phenprocoumon), or taking concomitant medications that increase the risk of bleeding
• Those with cardiovascular disease (heart ischemia and infarction)
• Those with systolic blood pressure<90mmHg or >140mmHg, or diastolic blood pressure <60mmHg or >90mmHg
• Those who have hypersensitivity reactions to "BR2008" or "BR2008-1"
• Pregnant woman, potentially pregnant woman, or breast-feeding woman