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NCT Number: NCT07571629

A 56-Day Exploratory Study of NatureU® Mind Care BeautyU Caps on Skin Aging Parameters

This was a 56-day, single-center, open-label, single-arm exploratory study evaluating within-participant changes in skin-aging parameters after daily oral intake of NatureU® Mind Care BeautyU Caps in adult women. Participants took one capsule daily for 56 days. The primary outcome was change from baseline in crow's-feet wrinkle count at Day 56 assessed by PRIMOS CR imaging. The secondary outcome was change from baseline in stratum corneum hydration at Day 56 assessed by Corneometer CM 825. Additional exploratory outcomes included other wrinkle topography parameters, skin elasticity, radiance, pigmentation, pore-related parameters, dermal thickness and density, and participant-reported skin appearance outcomes.

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Key information

Conditions

Skin Aging

Age range

36 year–56 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

CTI AiPu Medical Laboratory (Shanghai) Co., Ltd

Shanghai, Shanghai Municipality, 200040, China

About this study

The study was designed as an exploratory, signal-generating human evaluation of an oral nutricosmetic supplement. Adult female participants received NatureU® Mind Care BeautyU Caps once daily for 56 days and underwent skin assessments at baseline, Day 28, and Day 56. Instrumental assessments included PRIMOS CR imaging for wrinkle-related parameters and Corneometer CM 825 measurement for stratum corneum hydration. Additional skin-aging parameters were assessed using validated or commonly used skin analysis instruments according to the study protocol. The study was single-arm and open-label, with no placebo or parallel control group. Analyses were based on participants who completed the study assessments.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult woman aged 36 to 56 years, inclusive.
  • Healthy participant as judged by the investigator.
  • Cheek skin hydration below 60 C.U.
  • Visible crow's-feet wrinkles.
  • Facial laxity or reduced facial radiance.
  • At least one visible facial spot meeting the prespecified size and ITA value criteria.
  • Willing to take the study product once daily for 56 consecutive days.
  • Willing to complete scheduled skin assessments at baseline, Day 28, and Day 56.
  • Willing to maintain regular lifestyle habits during the study period.
  • Willing to avoid confounding skincare products, cosmetic procedures, medications, and health products during the study period.
  • Provided written informed consent before any study-related procedure.

Exclusion criteria

  • Skin condition that could interfere with study assessments.
  • Highly allergic constitution.
  • Known allergy or intolerance to any ingredient of the study product.
  • Pregnant or lactating.
  • Planned pregnancy during the study period.
  • Severe systemic illness.
  • Serious psychiatric disorder.
  • Serious endocrine disorder.
  • Recent participation in another clinical study.
  • Recent use of products or procedures that could influence skin outcomes.
  • Use of other oral or topical products that could interfere with skin-aging assessments during the study period.
  • Recent cosmetic dermatology procedures or treatments that could affect the target assessment areas.
  • Inability to comply with study procedures.
  • Any condition judged by the investigator to make participation inappropriate.

Treatment and study plan

NatureU® Mind Care BeautyU Caps

Dietary Supplement

An oral nutricosmetic supplement containing PQQ, quercetin, ergothioneine, cranberry polyphenols, and related formulation components. Participants took one capsule daily for 56 days.

Primary outcomes

  1. Change From Baseline in Crow's-Feet Wrinkle Count at Day 56

    Time frame: Baseline and Day 56

    Crow's-feet wrinkle count was assessed using PRIMOS CR imaging. The primary endpoint was the within-participant change from baseline to Day 56.

Secondary outcomes

  1. Change From Baseline in Stratum Corneum Hydration at Day 56

    Time frame: Baseline and Day 56

    Skin hydration was assessed using Corneometer CM 825. The secondary endpoint was the within-participant change from baseline to Day 56.

Other outcomes

  1. Change From Baseline in Additional Wrinkle Topography Parameters at Day 28 and Day 56

    Time frame: Day 28, Day 56

    Wrinkle Topography Parameters

Sponsors and collaborators

Lead sponsor

OmniSolutions Laboratory Holdings Limited

Industry

Registry information

Official study title

A 56-Day Single-Arm Exploratory Study of NatureU® Mind Care BeautyU Caps on Crow's-Feet Wrinkle Count, Skin Hydration, and Related Skin-Aging Parameters in Adult Women

Acronym: NUAA

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
May 6, 2026
Registry last updated
May 11, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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