Knowledge of Inborn Errors of Immunity Among Pediatric Physicians

This cross-sectional study aims to assess the level of knowledge regarding inborn errors of immunity among pediatric physicians working in Assiut Governorate, Egypt.

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Key information

Conditions

Primary Immunodeficiency Diseases Congenital, Hereditary, and Neonatal Diseases and Abnormalities Genetic Diseases, Inborn Immune System Diseases Immunologic Deficiency Syndromes

Age range

24 year and older

Sex eligibility

All sexes

Study type

Observational

About this study

Inborn errors of immunity (IEI) are heterogeneous disorders that can present with recurrent, severe, or unusual infections, autoimmunity, and other manifestations. Early recognition by pediatric physicians is important for timely diagnosis and management.

This observational study will use a self-administered electronic questionnaire to assess knowledge of clinical warning signs, general and specific signs of IEI, and treatment and immunization strategies among pediatric physicians in Assiut.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

- Working as a pediatric physician in Assiut
Practicing pediatrics in a participating hospital
Willing to participate and able to complete the electronic questionnaire
Providing informed consent

Exclusion criteria

- Refusal to participate
Inadequate or substantially incomplete questionnaire response
Not currently practicing pediatrics
Participation in questionnaire development or validation

Treatment and study plan

Primary outcomes

Overall knowledge score regarding inborn errors of immunity

Time frame: Baseline

Mean percentage score of correct answers on the knowledge questionnaire regarding inborn errors of immunity (maximum score expressed as percentage) Score ranges from 0 to 100%, with higher scores indicating better knowledge.

Secondary outcomes

Domain-Specific Knowledge Scores

Time frame: Baseline

Separate percentage scores for four domains: 1) Warning signs in children (4 questions) and adults (2 questions), 2) General signs of IEI (5 questions), 3) Specific signs of IEI (9 questions), 4) Treatment strategies and immunization (5 questions) Score ranges from 0 to 100%, with higher scores indicating better knowledge.
Knowledge scores according to professional and educational characteristics

Time frame: Baseline

Mean overall knowledge scores stratified by years of experience, educational level, hospital affiliation type, previous training in pediatric immunology, and daily case flow.Score ranges from 0 to 100%, with higher scores indicating better knowledge.
Mean knowledge scores by hospital

Time frame: Baseline

Comparison of mean overall knowledge scores across participating hospitals in Assiut Governorate to identify hospitals with greatest knowledge gaps requiring priority targeted educational and training activities. Interpreted in relation to number of participating physicians per hospital.Score ranges from 0 to 100%, with higher scores indicating better knowledge.

Interested in participating?

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Sponsors and collaborators

Lead sponsor

Assiut University

Other

Registry information

Official study title

Assessment of Knowledge Regarding Inborn Errors of Immunity Among Pediatric Physicians in Assiut: A Cross-Sectional Study

Important dates

Study start: 2026
Primary completion: 2027
Study completion: 2028
First posted: Sep 23, 2026
Registry last updated: Sep 25, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Not yet recruiting