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NCT Number: NCT07837154

Blood Flow Restriction Training in Knee Arthropathy

Arthrogenic muscle inhibition (AMI) is the key neurophysiological cause of impeding quadriceps activation following anterior cruciate ligament reconstruction (ACLR). Blood flow restriction training (BFRT) may induce neuroplasticity whereas the neurophysiological responses remain uncertain. In this study, we aimed to explore the effects of constant pressure blood flow restriction training (CP-BFRT) on neurophysiological responses and physical function. Patients will receive the same standardized progressive physical rehabilitation for 2 weeks after the surgery and then start the BRFT or sham BRFT intervention for the following 12 weeks.

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Key information

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

The Affiliated Hospital of Southwest Medical University

Luzhou, Sichuan, 646000, China

Location contact

Chi Zhang

CONTACT

[email protected]

86+13082566763

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Knee arthroscopy;
  • Age 18-60 years;
  • Ability to provide informed consent;
  • Availability for follow-up assessments;
  • Written informed consent.

Exclusion criteria

  • Neurological disorders affecting lower extremity function;
  • Vascular disease or coagulopathy;
  • Contralateral knee pathology;
  • Previous knee surgery;
  • inability to comply with rehabilitation protocols;
  • pregnancy.

Treatment and study plan

Blood flow restriction training with 60%-80% occlusion

Other

A personalized constant-pressure system served as the active BFRT unit, with restrictive pressure set at 60%-80% of limb arterial occlusion pressure; it auto-inflates to maintain constant pressure and automatically monitors, assesses, and adjusts pressure during training.

Other names: KAATSU Training, Occlusion Training

Standard postoperative knee rehabilitation with sham BFRT

Other

Standard postoperative rehabilitation protocol after knee arthroscopic surgery, without blood flow restriction training. The rehabilitation program includes range of motion exercises, muscle strength training, balance training and functional activity training, with the same schedule, frequency and duration as the experimental group.

Primary outcomes

  1. H-reflex Hmax/Mmax Ratio

    Time frame: From enrollment to the end of treatment at 12 weeks.

    H-reflex is a validated neurophysiological indicator for evaluating spinal-level AMI after knee surgery which is applied to assess resting spinal reflex excitability of the knee extensor motor pool vastus medialis.

    Unit of Measure: Ratio (dimensionless)

Secondary outcomes

  1. Knee Joint Position Sense (JPS) Accuracy

    Time frame: From enrollment to the end of treatment at 12 weeks.

    Knee proprioceptive acuity was evaluated using a calibrated isokinetic dynamometer. Participants were blindfolded to exclude visual interference and seated with the tested lower limb securely strapped to the dynamometer lever arm. The knee was passively positioned at three target flexion angles (30°, 60°, and 90°). After passive positioning and a 3-second holding phase, participants actively reproduced the perceived target angle independently. Absolute angular error was calculated as the absolute discrepancy between the preset target angle and the actively reproduced angle.

    Unit of Measure: Degrees (°)

  2. Somatosensory Evoked Potential (SEP) P40 Latency

    Time frame: From enrollment to the end of treatment at 12 weeks.

    Cortical somatosensory afferent function was assessed via tibial nerve somatosensory evoked potentials (SEP). The P40 latency was defined as the time interval from stimulus onset to the occurrence of the P40 positive wave, representing the conduction efficiency and temporal characteristics of peripheral proprioceptive signals transmitting to the primary somatosensory cortex.

    Unit of Measure: Milliseconds (ms)

  3. Somatosensory Evoked Potential (SEP) N45-P40 Peak-to-peak Amplitude

    Time frame: From enrollment to the end of treatment at 12 weeks.

    Central sensory integration plasticity was assessed via tibial nerve somatosensory evoked potentials (SEP). The N45-P40 peak-to-peak amplitude was calculated to evaluate cortical sensory gain and central inhibitory/excitatory balance.

    Unit of Measure: Microvolts (μV)

  4. Quadriceps rapid torque development rate (RTD)

    Time frame: From enrollment to the end of treatment at 12 weeks.

    Quadriceps rapid torque development rate (RTD) was measured to quantify the efficiency of central motor unit recruitment and neuromuscular rapid-driving capability. Quadriceps RTD was calculated as the rate of torque increase within the early contraction phase, reflecting the recruitment efficacy of high-threshold type II muscle fibers and synchronous firing of motor units.

    Unit of Measure: Nm/s

Study contacts

Contact information is provided by the study sponsor or research team.

Yuxiu Ji

CONTACT

[email protected]

86+0830-8950771

Sponsors and collaborators

Lead sponsor

Yuxiu Ji

Other

Registry information

Official study title

Effects of Blood Flow Restriction Training on Lower Limb Muscle Strength and Atrophy in Patients With Knee Arthropathy: A Randomized Controlled Trial

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Sep 23, 2026
Registry last updated
Sep 23, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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