ANCILLARY STUDY No. 3 NS-PARK-OMICS

Inclusion criteria

PATIENT GROUP -Enrolled in the NS-PARK cohort in the Parkinson's disease patient group, with sample collection for genetic analysis.

AT-RISK GROUP

-Enrolled in the at-risk group of the NS-PARK cohort, with sample collection for genetic analysis, in accordance with the NS-PARK cohort criteria, i.e.: Individual related to a patient with Parkinson's disease; And/or

• Unaffected individual carrying a mutation in a gene known to be involved in Parkinson's disease; And/or
• Individual presenting a prodromal form of the disease (e.g., idiopathic REM sleep behaviour disorder [iRBD]).

CONTROL GROUP (healthy volunteers)

• Individual matched for age and sex with the patient included in this study;
• No neurological disease or symptoms, as determined by the neurologist during the clinical interview, and no known history of neurological disease or symptoms.

FOR ALL GROUPS

• Adult individual;
• Affiliated with a social security scheme or entitled to benefits under such a scheme;
• Negative blood or urine pregnancy test prior to inclusion for women of childbearing potential;
• Having provided written, free and informed consent to participate in this research.

Exclusion criteria

• Individuals under judicial protection (sauvegarde de justice);
• Pregnant or breastfeeding women;
• Individuals under guardianship or curatorship;
• Known contraindication to lumbar puncture (as defined in the protocol).