Combined Nasal Goniotomy-Temporal Trabeculotomy Versus Temporal Trabeculotomy for Management of Primary Congenital Glaucoma

Combined nasal goniotomy and temporal trabeculotomy provides effective IOP control in PCG while preserving the superior conjunctiva for future filtering procedures. By expanding the treated angle area and sparing the superior conjunctiva, this operation provides a synergistic approach that may improve long-term management strategies for pediatric glaucoma

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Primary Congenital Glaucoma Congenital Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities Eye Abnormalities Eye Diseases Glaucoma Glaucoma, Open-Angle Hydrophthalmos Infant, Newborn, Diseases Ocular Hypertension

Age range

1 day–2 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Zagazig University

Zagazig, Sharqia Province, 44511, Egypt

About this study

Primary congenital glaucoma (PCG) is the main category of primary childhood glaucoma. Classically, PCG presents with one or more of the following clinical manifestations: increased corneal diameters, corneal opacification, photophobia, and excessive tearing. The increased intraocular pressure (IOP) in PCG is mainly due to an immature anterior chamber (AC) angle with inadequate aqueous filtration through the trabecular meshwork (TM). 1 Reduction of IOP in PCG relies mainly on surgical treatment. Wide variations in surgical procedures exist for the treatment of PCG, with different principles and steps. The idea behind angle-based surgeries is to remove the main barrier to aqueous filtration and create a direct pathway for aqueous to reach the Schlemm's Canal (SC). Other surgeries, such as trabeculectomy or implantation of Glaucoma drainage devices (GDD), divert the aqueous drainage toward the sub-tenon space away from the occluded TM.2,3 and 4 PCG treatment may entail the need for more than one surgery to correct the IOP. Combining two or more surgical procedures in the same setting may produce a synergistic effect in reducing the IOP while reducing the psychological and surgical burden on PCG patients. In the combined Nasal Goniotomy-Temporal Trabeculotomy (NGTT) procedure, preservation of the superior conjunctiva is an advantage that increases the success rates of further surgeries if needed. 5 In this study, the authors studied a real-world comparison between NGTT and single-site trabeculotomy for the management of PCG patients.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Child with primary congenital glaucoma

Exclusion criteria

associated ocular diseases other than glaucom
posterior segment congenital anomalies

Treatment and study plan

combined Nasal goniotomy-Temporal trabeculotomy

Procedure

Temporal trabeculotomy

Procedure

Temporal trabeculotomy

Primary outcomes

intra ocular pressure

Time frame: 1 YEAR

post operative IOP compared to preoperative IOP

Sponsors and collaborators

Lead sponsor

Zagazig University

Other Gov

Registry information

Important dates

Study start: 2024
Primary completion: 2026
Study completion: 2026
First posted: Sep 21, 2026
Registry last updated: Sep 21, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed