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NCT Number: NCT07827443

mFFE MRI Versus CT for Cortical Bone Evaluation in Knee Osteoarthritis

This cross-sectional study aims to evaluate the accuracy of multi-echo fast field echo (mFFE) MRI in depicting cortical bone changes in knee osteoarthritis compared with CT.

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Key information

Conditions

Osteoarthritis, Knee Arthritis Bone Diseases Joint Diseases Musculoskeletal Diseases Osteoarthritis Rheumatic Diseases

Age range

40 year and older

Sex eligibility

All sexes

Study type

Observational

About this study

Knee osteoarthritis involves microstructural alterations in subchondral and cortical bone. Conventional MRI has limitations in visualizing cortical bone due to short T2 relaxation times. Multi-echo fast field echo (mFFE) sequences can produce CT-like images of cortical bone without ionizing radiation.

This observational study will include patients aged 40 years or older with clinically suspected or confirmed knee osteoarthritis. All participants will undergo both mFFE MRI and CT of the knee. The accuracy of mFFE MRI in detecting cortical bone degenerative changes will be compared with CT as the reference standard.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • - Age 40 years or older
  • Clinically suspected or confirmed knee osteoarthritis
  • Able and willing to provide informed consent

Exclusion criteria

  • - Implanted electronic devices (pacemakers, ICDs, neurostimulators, cochlear implants)
  • Metallic foreign bodies in the eyes or orbits
  • Ferromagnetic cerebral aneurysm clips
  • Implantable infusion pumps
  • Pregnancy

Treatment and study plan

Primary outcomes

  1. Diagnostic accuracy of mFFE MRI for cortical bone changes

    Time frame: Baseline

    Overall diagnostic accuracy percentage of multi-echo fast field echo MRI in detecting cortical bone degenerative changes in knee osteoarthritis, using CT as the reference standard

Secondary outcomes

  1. Sensitivity of mFFE MRI for cortical bone changes

    Time frame: Baseline

    Sensitivity percentage of multi-echo fast field echo MRI in detecting cortical bone degenerative changes in knee osteoarthritis, using CT as the reference standard

  2. Specificity of mFFE MRI for cortical bone changes

    Time frame: Baseline

    Specificity percentage of multi-echo fast field echo MRI in detecting cortical bone degenerative changes in knee osteoarthritis, using CT as the reference standard

  3. Detection of subchondral sclerosis

    Time frame: Baseline

    Number of cases in which mFFE MRI correctly identifies subchondral sclerosis compared with CT

  4. Detection of osteophytes

    Time frame: Baseline

    Number of cases in which mFFE MRI correctly identifies osteophytes compared with CT

  5. Detection of joint space narrowing

    Time frame: Baseline

    Number of cases in which mFFE MRI correctly identifies joint space narrowing compared with CT

  6. Image quality score

    Time frame: Baseline

    Mean subjective image quality score of mFFE MRI for cortical bone visualization on a predefined scale from 1 to 5, with higher scores indicating better image quality

Study contacts

Contact information is provided by the study sponsor or research team.

Fatima M Eltony, Resident

CONTACT

[email protected]

+20 10 15712606

Sponsors and collaborators

Lead sponsor

Assiut University

Other

Registry information

Official study title

Beyond Conventional MRI: Multi-Echo Fast Field Echo (mFFE) MRI for Cortical Bone Evaluation in Knee Osteoarthritis Compared With CT

Important dates

Study start
2026
Primary completion
2027
Study completion
2028
First posted
Sep 18, 2026
Registry last updated
Sep 18, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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