A Study of RO7830698 in Healthy Participants and Participants With Chronic Obstructive Pulmonary Disease

Inclusion criteria

All participants:

• Body mass index (BMI) between 18 and 32 kilograms per meter square (kg/m2)
• Agreement to adhere to the contraception requirements

Part 1:

• Absence of evidence of any active or chronic disease

Part 2:

• Confirmed diagnosis of COPD for > 6 months, as defined by the Global Initiative for Chronic obstructive Lung Disease (GOLD) guidelines
• Using maintenance inhaled therapy that may include inhaled corticosteroids (ICS) and/or long-acting β-agonist (LABA) and/or long-acting muscarinic antagonist (LAMA) as separate inhaler(s) or in combination preparation(s)
• Current smoker or ex-smoker with a tobacco history of >= 10 pack years

Exclusion criteria

• Pregnant or breastfeeding, or planning to become pregnant during the study or within the timeframe in which contraception is required
• Current or chronic history of clinically significant liver disease or known hepatic or biliary abnormalities (with the exception of Gilbert syndrome or asymptomatic gallstones) or cirrhosis
• Known history of allergy to drugs or other substances, or clinically significant, acute, and/or uncontrolled allergic disease
• Known or suspected history of immunosuppression
• History of recurrent severe infections and underlying conditions predisposing participant to infections
• History of disseminated herpes simplex infection, or recurrent (> 1 episode) or disseminated herpes zoster
• Autoimmune disease requiring systemic immunosuppressive therapy
• History of or presence of any clinically significant unstable cardiovascular disease
• Treatment with medications targeting the same pathways as RO7830698, immunomodulatory/ immunosuppressive therapy, or licensed biologics for COPD and asthma within protocol-defined periods
• Positive results for hepatitis B infection, human immunodeficiency virus infection, or hepatitis C infection at the Screening visit
• Evidence of tuberculosis infection or disease
• Participation in any clinical study of a drug or medical device within protocol-defined periods
• Any other conditions that may affect providing informed consent or study protocol adherence, or if study participation may affect study results or participant safety