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NCT Number: NCT07807930

Individual Narratives of Stimulation (ECT and TMS)

Electroconvulsive therapy (ECT) and transcranial magnetic stimulation (TMS) are two evidence-based treatments for major depressive disorder. Both work by stimulating the brain (a process known as neuromodulation), but they differ markedly in invasiveness. ECT requires a general anaesthetic, whereas TMS is delivered while a person is awake and alert and they can go home immediately afterwards. TMS has been proposed as an alternative to ECT for some people. However, TMS is not as effective as ECT in all cases, is generally slower acting, and remains less widely available.

In Nottingham and Liverpool, we have identified a small number of individuals who have experienced both ECT and TMS across different episodes of depression. One such individual is a lived experience co-researcher on our team. Whilst previous studies have explored experiences of ECT and TMS separately, often using relatively superficial methods, none have examined the perspectives of people who have received both treatments. This study addresses that gap through an in-depth exploration of their experiences.

We will use a narrative inquiry approach that encourages participants to tell the story of their experiences of ECT and TMS in their own words. Eligible participants will be adults who have previously received both treatments for depression. Participation involves four sessions: a structured discussion to map the timeline of their depression and treatments, two in-depth open-ended interview sessions (narrative inquiry), and a follow-up discussion about the researchers' reconstruction of their story. Recruitment will take place through services in Nottingham and Liverpool.

This study will help us understand how patients relate to, and make sense of, ECT and TMS, which contextual factors shape their experiences, and how these treatments fit into broader recovery journeys. The findings will inform development of patient-centred services, support shared decision-making, and promote a compassionate understanding of treatment experiences among healthcare professionals.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Mersey Care NHS Foundation Trust, Liverpool, United Kingdom

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Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 18 years or older
  • Previously received at least one TMS and one ECT session as treatment for major depression
  • Conversational in the English language
  • Capacity to give informed consent to take part in this study
  • Feels fully informed and well enough to be able to share potentially distressing past experiences

Exclusion criteria

  • Participants may be excluded at the judgement of the PI if it is felt that the participant is at high risk of significant emotional distress from taking part in the interviews at this time

Treatment and study plan

There is no intervention in this observation study (qualitative interviews about past treatment experiences)

Other

There is no intervention in this observation study (qualitative interviews about past treatment experiences)

Primary outcomes

  1. Co-created narratives and associated themes

    Time frame: From enrollment to the completion of the follow-up feedback sesson

Study contacts

Contact information is provided by the study sponsor or research team.

Peggy Research Assistant (Liverpool)

CONTACT

[email protected]

+44

Sarah Research Assistant (Nottingham)

CONTACT

[email protected]

+44

Sponsors and collaborators

Lead sponsor

University of Nottingham

Other

Collaborators

  • Mersey Care NHS Trust

Registry information

Official study title

Lived Experience of People Who Have Received Both Electroconvulsive Therapy (ECT) and Transcranial Magnetic Stimulation (TMS) for Treating Major Depressive Disorder: a Narrative Inquiry

Acronym: INSight

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Sep 8, 2026
Registry last updated
Sep 8, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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