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Completed

NCT Number: NCT07807085

Apple Peptide Complex for Post-Surgical and Aesthetic Skin Recovery

This clinical study evaluates a topical botanical formulation for supporting skin recovery following invasive and non-invasive aesthetic procedures. These procedures include liposuction, breast augmentation, Brazilian butt lift (BBL), laser treatments, and micro needling, pregnancy stretch mark and weight loss skin.

The study will assess the effects of the formulation on skin elasticity, hydration, and overall appearance when used as part of post-procedure care under the supervision of licensed medical professionals. Participants will apply the product to treatment areas over a defined study period, and outcomes will be compared to a control group receiving standard care or placebo.

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Key information

Conditions

Skin Barrier to Water Loss Breast Augmentation and Breast Reconstruction Breast Reconstruction Chemotherapy Effects Congenital Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities Hemic and Lymphatic Diseases Hyperpigmentation Hyperpigmentation; Melanin Lymphatic Abnormalities Lymphatic Diseases Pathological Conditions, Signs and Symptoms Pigmentation Disorders Signs and Symptoms Skin Abnormalities Skin Discoloration Skin Diseases Skin Health Skin Irritation Skin Manifestations Skin and Connective Tissue Diseases Stretch Mark Striae Distensae

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Grow Out Oils Clinical Aromatherapy Company

Weston, Florida, 33326, United States

About this study

The investigational product is a topical botanical formulation composed of plant-derived extracts including Pyrus malus (apple) fruit extract, Vanilla planifolia fruit extract, Jasminum officinale (jasmine) flower extract, and Vitis vinifera derivatives. These components are commonly used in dermatologic and cosmetic applications for their antioxidant, emollient, and skin barrier-supporting properties.

The formulation contains fatty acid components, including linoleic acid, which may contribute to maintaining skin hydration and barrier integrity. The product is intended for topical use following invasive and non-invasive aesthetic procedures, including liposuction, breast augmentation, Brazilian butt lift (BBL), laser therapies, and micro needling, pregnancy stretch mark and weight loss skin.

This study is designed as a randomized, interventional clinical trial conducted in medical aesthetic clinics, dermatology practices, and med spa settings. Participants were assigned to either an intervention group receiving the investigational product for standard post-procedure usage for topical skincare use.

Primary outcome measures include assessment of skin elasticity, hydration, and visible skin appearance. Secondary outcomes include time to visible recovery and incidence of adverse skin reactions.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Female participants aged 45-65 years
  • Undergoing or have undergone aesthetic or surgical procedures (e.g., liposuction, breast augmentation, laser treatments, microneedling)
  • Presence of skin concerns such as hyperpigmentation, scarring, or reduced elasticity
  • Willing and able to comply with study procedures and follow-up
  • Physician clearance for participation

Exclusion criteria

  • Active skin infections, open wounds, or delayed wound healing
  • Pregnancy or breastfeeding
  • Use of conflicting topical or systemic treatments
  • Known allergy to botanical ingredients in the formulation

Treatment and study plan

Apple Peptide Complex Post-Aesthetic Care Protocol

Other

Participants receive the Apple Peptide Complex topical formulation as a standardized post-aesthetic care intervention following invasive and non-invasive aesthetic procedures. Participants apply the formulation to designated treatment areas according to the protocol-defined frequency, amount, and duration. Outcomes are evaluated to assess the formulation's effects on post-procedural skin recovery and overall cellular repair. Apple Peptide Complex is administered topically as a standardized post-aesthetic care intervention following invasive and non-invasive aesthetic procedures. Participants apply the formulation to designated treatment areas according to protocol-defined instructions regarding frequency and duration. The study evaluates predefined outcomes associated with post-procedural recovery and overall cellular repair.

Primary outcomes

  1. Clinician-Graded Visual Skin Evaluation Score

    Time frame: Baseline, Day 14, and Day 28 post-procedure

    Clinician assessment of skin surface appearance to monitor reductions in post-procedural redness and dryness. Evaluation is performed using a standard 0 to 4 scale, where 0 indicates no redness/dryness and 4 indicates severe redness/dryness. Unit of Measure: Units on a scale (0 to 4)

  2. Change in Trans epidermal Water Loss (TEWL)

    Time frame: 28 days post-procedure (with assessments conducted at day 14 and day 28)

    Evaluation of skin barrier function following daily topical use of the cosmetic Apple Peptide Complex. Data are collected via a tewameter to assess absolute changes in skin moisture retention. Unit of Measure: g/h/m²

  3. Participant Comfort Rating Score

    Time frame: Baseline, Day 14, and Day 28 post-procedure

    Self-reported participant feedback regarding skin comfort, including soothing sensations and lack of irritation. Scores are recorded using a feedback scale from 0 (extreme discomfort/irritation) to 10 (complete skin comfort/highly soothed). Unit of Measure: Units on a scale (0 to 10)

Secondary outcomes

  1. Presence of Post-Inflammatory Hyperpigmentation (PIH)Description

    Time frame: Baseline (pre-procedure), immediately post-procedure, Day 14, and Day 28

    Clinical observation of the treated area to identify the development of post-procedural hyperpigmentation. Unit of Measure: Percentage of participants with observed hyperpigmentation.

  2. Clinician-Graded Skin Desquamation Score

    Time frame: Baseline (pre-procedure), immediately post-procedure, Day 14, and Day 28

    Assessment of skin flaking or peeling in the treated area using a standard clinical scaling chart. Evaluation is graded on a 0 to 4 scale, where 0 indicates no desquamation and 4 indicates severe desquamation.

Other outcomes

  1. Clinician-Rated Skin Erythema Score

    Time frame: Baseline (pre-procedure), immediately post-procedure, Day 14, and Day 28

    Assessment of skin redness in the treated area using a localized erythema grading scale. Evaluation is graded on a 0 to 3 scale, where 0 indicates no erythema and 3 indicates severe erythema. Unit of Measure: Units on a scale (0 to 3)

Sponsors and collaborators

Lead sponsor

Grow Out Oils Clinical Aromatherapy Company

Industry

Registry information

Official study title

Evaluation of the Efficacy of the Breast and Body Apple Peptide Complex in Post-Surgical Recovery and Non-Invasive Aesthetic Treatments in Medical Aesthetic Clinics, Dermatology Practices, and Med Spas

Acronym: APC-SKIN

Important dates

Study start
2021
Primary completion
2025
Study completion
2025
First posted
Sep 8, 2026
Registry last updated
Sep 8, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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