Activating Voice Journaling for Mental Health With Voice Biomarkers

This retrospective observational study evaluated the relationship between voice characteristics and self-reported mental health symptoms using longitudinal data collected through the Kintsugi Voice Journaling app. Participants provided voice recordings and completed the Patient Health Questionnaire-9 (PHQ-9) and Generalized Anxiety Disorder-7 (GAD-7) over time. The study analyzed previously collected data to evaluate whether voice biomarkers could be associated with symptoms of depression and anxiety.

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Key information

Conditions

Depression / Major Depressive Disorder Anxiety Anxiety Disorders Behavior Behavioral Symptoms Depression Depressive Disorder Depressive Disorder, Major Mental Disorders Mood Disorders Personal Satisfaction Psychological Well-Being

Sex eligibility

All sexes

Study type

Observational

Primary location

Kintsugi Mindful Wellness, Inc.

Berkeley, California, 94707, United States

About this study

This retrospective observational cohort study analyzed previously collected longitudinal data from users of the Kintsugi Voice Journaling app. Participants voluntarily recorded voice samples through the app and completed standardized self-report measures of depression and anxiety, including the Patient Health Questionnaire-9 (PHQ-9) and Generalized Anxiety Disorder-7 (GAD-7), over a period of several years.

The study population included individuals who used the Kintsugi Voice Journaling app and contributed voice recordings and mental health questionnaire data. No intervention was assigned as part of this study, and no additional data were collected specifically for the research analysis.

The analysis evaluated associations between features derived from participants' voice recordings and self-reported symptoms of depression and anxiety. The study was conducted using previously collected observational data from approximately 50,000 participants.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Use of the Kintsugi Voice Journaling app during the observation period
Previously collected voice recording data available from use of the app
At least one completed PHQ-9 and/or GAD-7 assessment during the observation period

Exclusion criteria

None; no participants meeting the inclusion criteria were excluded from the analysis

Treatment and study plan

Primary outcomes

Association Between Voice Biomarkers and Depressive Symptom Severity (PHQ-9)

Time frame: Through study completion, up to 24 months

Association between voice biomarkers and depressive symptom severity as measured by the Patient Health Questionnaire-9 (PHQ-9). The PHQ-9 is a 9-item self-report measure of depressive symptom severity; each item is scored 0-3 and total scores range from 0 to 27, with higher scores indicating greater (worse) depressive symptom severity.

Secondary outcomes

Association Between Voice Biomarkers and Anxiety Symptom Severity (GAD-7)

Time frame: Through study completion, up to 24 months

Association between voice biomarkers and anxiety symptom severity as measured by the Generalized Anxiety Disorder-7 (GAD-7). The GAD-7 is a 7-item self-report measure of anxiety symptom severity; each item is scored 0-3 and total scores range from 0 to 21, with higher scores indicating greater (worse) anxiety symptom severity.

Sponsors and collaborators

Lead sponsor

Kintsugi Mindful Wellness, Inc.

Industry

Registry information

Official study title

Activating Voice Journaling for Mental Health With Voice Biomarkers: Observational Study

Important dates

Study start: 2019
Primary completion: 2021
Study completion: 2021
First posted: Aug 27, 2026
Registry last updated: Aug 27, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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