Feasibility of Remote Monitoring of Patients With Myasthenia Gravis

Inclusion criteria

Subject

• Has the capacity to understand and sign an informed consent form
• ≥18 years old
• Diagnosed with acquired autoimmune MG based on clinical syndrome and seropositivity for MG associated autoantibodies (AChR binding, MuSK, or LRP4 antibodies), and/or a decremental response on repetitive nerve stimulation, positive single fiber electromyography (EMG) or positive edrophonium test
• Subject has been previously evaluated in a face-to-face clinical encounter at participating study site or referral site within the prior 3 years
• Primary language is English, or equivalent level of English language fluency
• Required disease severity range previously judged by the Investigator. MGFA class 1-4a within 3 years of diagnosis without other chronic medical conditions, which compromise participation.
• Having MG-ADL score above 2 upon entrance to study
• Patients considered by study PI not to require hospitalization at time of entrance
• The patient has internet capability and a smart phone compatible with the apps required by the study.

Exclusion criteria

Disease Specific Exclusion Criteria

• Inability to comply with study protocol for monitoring
• Current MGFA Severity Class IVb or V, or patients in remission with MGFA Class 0
• Any significant medical/psychiatric condition that, in the opinion of the Investigator, may interfere with interpretation of subject evaluation(s) or protocol compliance
• Any disorder that could limit ability to assess myasthenia gravis specific deficits (not including planned or recent thymectomy)
• Pregnancy, based on the evaluator's judgment, if the subject is deemed not safe to undergo evaluation or comply with study visit requirements.
• Lack of effective internet connection or ability to use study telemedicine station and monitors
• Home environment prevents use of study equipment
• Likelihood of leaving DC, Maryland, or Virginia area in year after initiation of study
• Subject is already participating in a research study -