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NCT Number: NCT07760194

Evaluation of Fetal Heart

Evaluation of fetal cardiac functions in cases complicated with growth restriction

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Key information

About this study

10% of pregnancies are, by the description, affected by the common obstetric issue known as intrauterine growth restriction (IUGR). IUGR is a significant contributor to prenatal mortality and morbidity. Cardiomyopathy is a reliable marker of the advancement of IUGR; in these babies, it begins during the early phases of fetal growth restriction and worsens as fetal impairment advances. IUGR is caused by placental dysfunction and this leads to a state of chronic hypoxia and metabolic stress and redistribution of blood flow towards vital organs, such as the brain, heart and adrenal glands. This hemodynamic compensation can itself contribute to a progressive deterioration of fetal cardiac function and myocardial remodeling. The myocardial performance index (MPI), also known as the Tei index, has emerged as a promising tool for the non-invasive evaluation of global fetal cardiac function, integrating both systolic and diastolic performance. To overcome some of the reproducibility-related limitations of the original technique, a modified version of the MPI (Mod-MPI) was introduced, which uses the opening and closing 'clicks' of the heart valves as more precise temporal landmarks. In recent years, numerous studies have investigated the role of MPI in the assessment of IUGR fetuses, and have suggested that this index may be altered early in gestation in response to chronic hypoxia and hemodynamic stress.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • pregnant women
  • more than 28 weehs gestation

Exclusion criteria

  • intrauterine fetal death

Treatment and study plan

Echocardiography

Procedure

Modified MPI is obtained by placing the Doppler sample volume on the medial wall of the ascending aorta including the AV and MV, hence the movements of both valves are recorded simultaneously in the Doppler spectrum through measurements of the isovolumetric contraction time (ICT), isovolumetric relaxation time (IRT) and ejection time (ET). The isovolumetric contraction time (ICT) was measured from the closure of the MV to the opening of the AV, the ejection time (ET) from the opening to the closure of the AV, and the isovolumetric relaxation time (IRT) from the closure of the AV to the opening of the MV. The MPI (Tei index) was calculated using the following equation: MPI= (ICT + IRT)/ET

Primary outcomes

  1. Measurement of MPI

    Time frame: 2 weeks

    Increased MPI means bad outcome

Study contacts

Contact information is provided by the study sponsor or research team.

Mohamed Fekry

CONTACT

[email protected]

+20882312388

Sponsors and collaborators

Lead sponsor

Assiut University

Other

Registry information

Official study title

Evaluation of Systolic and Diastolic Cardiac Functions in Fetuses With IUGR

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Aug 12, 2026
Registry last updated
Aug 13, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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