Women's Health Hospital
Asyut, Egypt
Location status: Recruiting
NCT Number: NCT07760194
Evaluation of fetal cardiac functions in cases complicated with growth restriction
Interested in participating?
Request InfoFemale
Observational
Asyut, Egypt
Location status: Recruiting
10% of pregnancies are, by the description, affected by the common obstetric issue known as intrauterine growth restriction (IUGR). IUGR is a significant contributor to prenatal mortality and morbidity. Cardiomyopathy is a reliable marker of the advancement of IUGR; in these babies, it begins during the early phases of fetal growth restriction and worsens as fetal impairment advances. IUGR is caused by placental dysfunction and this leads to a state of chronic hypoxia and metabolic stress and redistribution of blood flow towards vital organs, such as the brain, heart and adrenal glands. This hemodynamic compensation can itself contribute to a progressive deterioration of fetal cardiac function and myocardial remodeling. The myocardial performance index (MPI), also known as the Tei index, has emerged as a promising tool for the non-invasive evaluation of global fetal cardiac function, integrating both systolic and diastolic performance. To overcome some of the reproducibility-related limitations of the original technique, a modified version of the MPI (Mod-MPI) was introduced, which uses the opening and closing 'clicks' of the heart valves as more precise temporal landmarks. In recent years, numerous studies have investigated the role of MPI in the assessment of IUGR fetuses, and have suggested that this index may be altered early in gestation in response to chronic hypoxia and hemodynamic stress.
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
Modified MPI is obtained by placing the Doppler sample volume on the medial wall of the ascending aorta including the AV and MV, hence the movements of both valves are recorded simultaneously in the Doppler spectrum through measurements of the isovolumetric contraction time (ICT), isovolumetric relaxation time (IRT) and ejection time (ET). The isovolumetric contraction time (ICT) was measured from the closure of the MV to the opening of the AV, the ejection time (ET) from the opening to the closure of the AV, and the isovolumetric relaxation time (IRT) from the closure of the AV to the opening of the MV. The MPI (Tei index) was calculated using the following equation: MPI= (ICT + IRT)/ET
Time frame: 2 weeks
Increased MPI means bad outcome
Contact information is provided by the study sponsor or research team.
Assiut University
Other
Evaluation of Systolic and Diastolic Cardiac Functions in Fetuses With IUGR
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
Published trials that share one or more normalized conditions with this study.
NCT07015203
Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Most, Czechia
View Trial DetailsNCT06497959
Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Female Urogenital Diseases and Pregnancy Complications
Nancy, France
View Trial DetailsNCT03662178
Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Death
Oxford, Oxfordshire, United Kingdom
View Trial DetailsNCT06919692
Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Female Urogenital Diseases and Pregnancy Complications
Aurora, Colorado, United States
View Trial Details