A Trial of Itraconazole Effect on HRS-8080 Pharmacokinetics in Healthy Participants

Inclusion criteria

• Aged 18-55 years;
• Male weight ≥ 50 kg, female weight ≥ 45 kg, and body mass index (BMI): 19-28 kg/m2;
• Normal or no clinically significant medical history, ECGs, vital signs and laboratory tests;
• Take contraception.

Exclusion criteria

• Any serious clinical diseases or medical history or diseases that affect the absorption, metabolism and/or excretion of the study drug;
• Severe infection, severe trauma or major surgery;
• Any medications in the two weeks before screening or baseline period;
• History of blood donation or severe blood loss;
• Have been vaccinated within 3 months before the screening or baseline period;
• History of smoking or excessive alcohol or drug abuse;
• History of excessive amounts of tea, coffee or caffeinated beverages, special foods; or have special dietary requirements;
• Other situations in which the researcher judges unsuitable.