Rocklatan Retinal Perfusion OCT Study

Inclusion criteria

• Patients with both eyes with open angle glaucoma.
• Abnormal VF (glaucomatous pattern with PSD abnormal at p<0.05 or GHT outside normal limits) on most recent two clinic visits on chart review
• Glaucomatous disc abnormality on chart review and confirmed on baseline disc photograph
• Overall average NFL thickness > 55 μm measured by Heidelberg Spectralis OCT -Glaucoma Module Premium Edition (chart review), consistent with early glaucoma
• NFLP-CD deficit (below 5 percentile of normal) in any of the 8 sectors on the initial baseline visit
• The difference in baseline NFLP-CD between the left and right eye should be less than 5% (% of area).
• IOP >= 17 mm Hg on the most recent two clinic visits (chart review) after monotherapy with latanoprost in both eyes.

Exclusion criteria

• Best corrected visual acuity worse than 20/30 on chart review of most recent clinic visit
• Age < 21 years at baseline
• Eye disease that could affect VF, NFL thickness, or NFLP (e.g., visually significant cataract, AMD, diabetic retinopathy, and optic neuropathy) at any study visit
• OCT and OCTA scans not meeting quality criteria at baseline
• Inability to cooperate with study procedures
• Inability to commit to the study visits