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NCT Number: NCT07058727

Different Hemostatic Agents Used in Partial Pulpotomy on Pulp Survival and Postoperative Pain

This randomized clinical trial evaluates the efficacy of sodium hypochlorite (NaOCl), chlorhexidine (CHX), and cold saline as hemostatic agents in partial pulpotomy. The study compares postoperative pain (via VAS scores) and pulp survival (via clinical/radiographic evaluation) at 1, 3, 7 days, 6 months, and 12 months

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Key information

Conditions

Efficacy of Hemostatic Agents Neurologic Manifestations Pain Pain, Postoperative Partial Pulpotomy Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Postoperative Pain Signs and Symptoms

Age range

15 year–55 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Çukurova Üniversitesi Diş Hekimliği Fakültesi

Adana, Sarıçam, 01250, Turkey (Türkiye)

Location status: Recruiting

Location contact

Yaren Coşğun, Dr.

CONTACT

[email protected]

+90 544 745 8633

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Permanent teeth with carious pulp exposure (no spontaneous pain).
  • Positive vitality test (Endo-Ice).
  • No periapical radiolucency.

Exclusion criteria

  • Systemic diseases affecting healing.
  • Pregnancy.
  • Non-vital pulp/necrosis

Treatment and study plan

Sodium Hypochlorite 2,5%

Drug

2.5% NaOCl applied for 1 min to exposed pulp for hemostasis, followed by standard pulp capping

Chlorhexidine

Drug

2% CHX applied for 1 min to achieve hemostasis, with identical subsequent steps to NaOCl group

Cold Saline

Drug

Hemostasis via 4°C saline (1 Min), then standardized pulp capping

Primary outcomes

  1. Postoperative Pain

    Time frame: 1 week

    The patient will be asked to rate the pain on the 1st, 3rd and 7th day according to VAS. (The patient is asked to score their pain in this range, with 0 being the lowest and 10 being the highest.)

  2. Pulp Survival Rate

    Time frame: 12 months

    The pulp is expected to be vital, without percussion tenderness and without spontaneous pain

Secondary outcomes

  1. Clinical Success

    Time frame: 12 months

    Maintaining the integrity of the restoration No need for endodontics treatments

Sponsors and collaborators

Lead sponsor

Cukurova University

Other

Registry information

Official study title

The Effect of Different Hemostatic Agents Used in Partial Pulpotomy on Pulp Survival and Postoperative Pain: A Randomized Clinical Trial

Important dates

Study start
2025
Primary completion
2025
Study completion
2026
First posted
Jul 10, 2025
Registry last updated
Apr 1, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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