The Relationship Between Osteoporosis and Sarcopenia Parameters in Postmenopausal Women Under 60

This cross-sectional study will include postmenopausal women under the age of 60 who visited the Physical Medicine and Rehabilitation outpatient clinic at Beylikdüzü State Hospital between June 25 and July 25, 2025. Participants must have undergone a bone mineral density (BMD) assessment within the past six months using Dual X-ray Absorptiometry (DXA). Both osteoporotic and non-osteoporotic patients will be enrolled. Sociodemographic data such as age, height, weight, and BMI will be recorded. Femoral neck and L1-L4 T-scores and BMD values will be obtained from existing DXA results. Information on osteoporosis treatment, presence of fecal incontinence, constipation, and medication use will be collected. In the second phase, sarcopenia will be assessed according to EWGSOP2 criteria using bioelectrical impedance analysis for skeletal muscle mass, handgrip strength, and the five-time sit-to-stand test. Differences between the osteoporotic and non-osteoporotic groups will be analyzed.

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Key information

Conditions

Osteoporosis Bone Diseases Bone Diseases, Metabolic Metabolic Diseases Musculoskeletal Diseases Nutritional and Metabolic Diseases

Age range

50 year–59 year

Sex eligibility

Female

Study type

Observational

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Women under 60 years of age who are postmenopausal.
Patients with or without a diagnosis of osteoporosis:

Osteoporosis group: T-score ≤ -2.5 in femoral neck or L1-L4 region. Control group: T-score ≥ -1.0 in femoral neck and L1-L4 region.

-Patients who provide written informed consent to participate in the study.

Exclusion criteria

Refusal to participate in the study.
Presence of neuromuscular diseases that could cause muscle loss.
History of infection, recent surgery, or trauma.
Presence of psychiatric disorders.
Cognitive impairment that could interfere with test performance or data reliability.
Use of medications that could affect study outcomes (e.g., corticosteroids, muscle relaxants, or medications influencing bone/muscle metabolism).

Treatment and study plan

Primary outcomes

Skeletal Muscle Mass

Time frame: 0 day

Measured by bioelectrical impedance analysis (BIA), this assesses the amount of muscle tissue in the body. Low skeletal muscle mass indicates sarcopenia.
Handgrip Strength

Time frame: 0 day

This is a simple test to measure muscle strength. Reduced handgrip strength is a sign of sarcopenia.
5 times chair stand test

Time frame: 0 day

The Five Times Sit-to-Stand Test is a simple and widely used functional assessment tool to evaluate lower extremity muscle strength, balance, and mobility.

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Sponsors and collaborators

Lead sponsor

Beylikduzu State Hospital

Other

Registry information

Official study title

The Relationship Between Osteoporosis and Sarcopenia Parameters in Postmenopausal Women Under 60: A Cross-Sectional Study

Important dates

Study start: 2025
Primary completion: 2025
Study completion: 2025
First posted: Jul 1, 2025
Registry last updated: Jul 1, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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