Wearable Sensors to Detect Atypical Muscle Activation in Young Infants

Inclusion criteria

• For Infants with low tone:
• Hospitalized in the NICU
• AND >38 weeks post-menstrual age
• AND abnormal normal brain imaging OR Apgar score <7 at five minutes with umbilical cord pH (if obtained) <7.15
• AND 2 or more warning signs for muscle tone or posture using the HNNE short form
• AND legal guardian able and willing to give written consent and comply with study procedures
• For Infants with typical tone:
• Born at 38-41 weeks of gestation
• AND hospitalized after birth in the NICU OR well newborn nursery
• AND infants with appropriate for gestational age birth weight
• AND HNNE exam (short proforma) normal with no warning signs for any parameter
• AND legal guardian able and willing to give written consent and comply with study procedures.

Exclusion criteria

• Infants of Both Low Tone and Typical Tone Cohorts:
• Missing or incomplete limbs (such as from amputation or congenital limb defects).
• Open wounds or skin breakdown on the limbs or torso.
• Presence of known genetic syndrome or congenital anomalies requiring surgery or affecting function
• Use of sedative medications (may include phenobarbital if level stable and therapeutic)
• Legal guardian unable to give written consent and comply with study procedures.
• Does not receive medical clearance from a physician to participate in the study if the individual is receiving inpatient care.