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Completed

NCT Number: NCT06569537

Comparison of Compounded Topical Anesthetics

The primary objective for this pilot study is to evaluate the efficacy of the compounded topical anesthetic Benzocaine 20%/ Lidocaine 8%/Tetracaine 4% (BLT) compared to 4% Lidocaine topical in providing relief of pain during IPL, PDL, and microneedling procedures.

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Key information

Conditions

Procedural Pain Neurologic Manifestations Pain Pain, Procedural Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Dartmouth Hitchcock Dermatology Clinic

Lebanon, New Hampshire, 03766, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Men and women over 18, but not more than 75 years of age.
  • Patients who have a regularly scheduled dermatology appointment for Intense Pulse Light (IPL), Pulse Dye Laser (PDL), or microneedling.

Exclusion criteria

  • Any subject who has a previous history of allergy, sensitivity, and contraindication to benzocaine, lidocaine, or tetracaine.
  • Patients with cardiac/respiratory disease, seizure disorder, or neuropathies.
  • Patients who are under treatment for a dermatologic condition that may interfere with the evaluation of the study.
  • Pregnant women and women who are breastfeeding.
  • Patients who report concurrent use of anxiolytics or opiates, which may interfere with the interpretation of results.

Treatment and study plan

Lidocaine topical

Drug

4%

BLT

Drug

Topical Benzocaine 20%/ Lidocaine 8%/Tetracaine 4%

Primary outcomes

  1. Pain as measured by the Numeric Pain Rating Scale (NPRS)

    Time frame: At baseline

    The NPRS pain scale is a segmented numeric version of the visual analog scale (VAS) in which a respondent selects a whole number (0-10 integers) that best reflects the intensity of his/her pain.

  2. Pain as measured by the Wong-Baker Face Pain Rating Scale

    Time frame: At baseline

    This scale shows a series of six faces ranging from a happy face at "no hurt" to a crying face at "hurts worst".

Sponsors and collaborators

Lead sponsor

Dartmouth-Hitchcock Medical Center

Other

Registry information

Official study title

Comparison of Compounded Topical Anesthetics for Pain Relief of Intense Pulsed Light, Pulse Dye Laser, and Microneedling Treatments

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Aug 26, 2024
Registry last updated
May 5, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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