Use of 18F-PSMA-11 PET for Detection of Lesions in Iodine Refractory Thyroid Cancers

Inclusion criteria

• Patient is 18 years or older.
• Signed Informed Consent.
• Subject is diagnosed with a histologically confirmed differentiated thyroid carcinoma, that is considered RAI refractory. There is evidence of persisting or recurrent disease, based on serum thyroglobulin levels and/or medical imaging.
• Subject should have a routine clinical 18F-FDG PET/CT performed within two months prior to the study scan.
• Female patients should be either post-menopausal, surgically sterile, or using highly effective contraceptives (methods that can achieve a failure rate of less than 1%: combined hormonal contraception, progestogen-only hormonal contraception associated with inhibition of ovulation, intrauterine device, intrauterine hormone-releasing system, bilateral tubal occlusion, vasectomized partner, sexual abstinence).

Exclusion criteria

• Patient has a known other active malignancy.
• Subject is potentially pregnant (urinary test can be performed in case of doubt) or breastfeeding.
• Patient is mentally or legally incapacitated.