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NCT Number: NCT03936140

The Effect of Iloprost on Oxygenation During One-lung Ventilation for Lung Surgery

During one-lung ventilation in patients undergoing thoracic surgery, the persistent flow in the non-ventilated lung increases intrapulmonary shunt and decreases systemic arterial oxygenation. This prospective, randomized, double blind study was conducted to evaluate the effects of inhaled iloprost during one-lung ventilation on arterial oxygenation and shunt fraction during thoracic surgery.

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Key information

Conditions

Lung Cancer Lung Diseases Lung Neoplasms Neoplasms Neoplasms by Site Respiratory Tract Diseases Respiratory Tract Neoplasms Thoracic Neoplasms

Age range

20 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Seoul St.Mary's Hospital

Seoul, South Korea

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • elective video-assisted thoracoscopic surgery (VATS) lobectomy
  • 20 < age < 75
  • American Society of Anesthesiologists (ASA) classification I~III

Exclusion criteria

  • ASA classification IV
  • New York Heart Association (NYHA) class III~IV
  • Severe obstructive lung disease / restrictive lung disease
  • Pulmonary hypertension
  • End-stage organ disease (i.e. hepatic failure, renal failure)
  • Arrhythmia
  • Previous history of thoracic surgery

Treatment and study plan

Inhaled ILOPROST

Drug

Study drug was inhaled to ventilated lung through a nebulized system in inspiratory limb after one-lung ventilation in the lateral decubitus position.

distilled water

Drug

Study drug was inhaled to ventilated lung through a nebulized system in inspiratory limb after one-lung ventilation in the lateral decubitus position.

Primary outcomes

  1. PaO2(partial pressure of arterial oxygen)

    Time frame: 30 min after treatment

    ABGA

  2. Pulmonary shunt fraction

    Time frame: 30 min after treatment

    Qs/Qt = (CcO2-CaO2) / (CcO2-CvO2)

Sponsors and collaborators

Lead sponsor

Seoul St. Mary's Hospital

Other

Collaborators

  • The Catholic University of Korea

Registry information

Official study title

The Effect of Iloprost on Arterial Oxygenation and Shunt Fraction During One-lung Ventilation for Lung Surgery

Important dates

Study start
2018
Primary completion
2018
Study completion
2018
First posted
May 3, 2019
Registry last updated
May 3, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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