HIV Self-Testing AND Uptake and Retention of PrEP Among Older Adolescent MSM and TGW

All eligible participants will be followed up at month 3, 6, 9, and 12; month 6 and 12 will be mandatory clinic visits, while month 3 and 9 will be either clinic or a virtual visits. For participants accepting PrEP, additional follow-up visit at month 1, 2, 4, and 5 will be appointed; all visits will be either clinic or virtual visits.

Study Sites

The study will take place at the following community-based clinics:

• SWING DIC, Bangkok, Thailand
• RSAT DIC, Bangkok, Thailand
• SWING DIC, Chonburi, Thailand
• Sister DIC, Chonburi, Thailand
• Caremat DIC, Chiang Mai, Thailand
• MPlus DIC, Chiang Mai, Thailand
• RSAT DIC, Songkhla, Thailand

Inclusion criteria

• Thai nationality
• Age 15-19 years old
• Men or transgender women who have sex with men
• HIV-negative at the time of screening
• Have at least one of the following risks for HIV acquisition in the past 6 months:

• Any unprotected receptive anal sex with a male partner
• More than 5 male partners, regardless of condom use and serostatus
• Has had a bacterial sexually transmitted infection (STI)
• Any injected drug use
• Calculated creatinine clearance (CrCl) ≥ 75 mL/min, as estimated by the Cockcroft- Gault equation
• Alanine aminotransferase (ALT) ≤ 2.5 x ULN
• Have signed the informed consent form

Exclusion criteria

• HIV-positive
• Hepatitis B infection as indicated by positive hepatitis B surface antigen (HBsAg) test at time of screening
• Known allergy/sensitivity to tenofovir or emtricitabine